Mechanical outcome of accelerated corneal crosslinking evaluated by Brillouin microscopy.

Purpose: To quantify corneal mechanical changes induced by corneal crosslinking (CXL) procedures of different ultraviolet-A (UVA) intensity and exposure time using Brillouin microscopy.

Settings: University of Maryland, College Park, Maryland, USA.

Design: Experimental study.

Biomechanical Changes After LASIK Flap Creation Combined With Rapid Cross-Linking Measured With Brillouin Microscopy.

Purpose: To evaluate the biomechanical changes occurring after LASIK flap creation and rapid corneal cross-linking (CXL) measured with Brillouin light microscopy.

Methods: Porcine eyes (n = 11) were evaluated by Brillouin light microscopy sequentially in the following order: virgin state, after LASIK flap creation, and after rapid CXL. Each eye served as its own control.

Calibration of optical coherence tomography angiography with a microfluidic chip.

A microfluidic chip with microchannels ranging from 8 to 96  μm was used to mimic blood vessels down to the capillary level. Blood flow within the microfluidic channels was analyzed with split-spectrum amplitude-decorrelation angiography (SSADA)-based optical coherence tomography (OCT) angiography. It was found that the SSADA decorrelation value was related to both blood flow speed and channel width.

Optical Coherence Tomography Angiography.

Optical coherence tomography angiography (OCTA) is a noninvasive approach that can visualize blood vessels down to the capillary level. With the advent of high-speed OCT and efficient algorithms, practical OCTA of ocular circulation is now available to ophthalmologists. Clinical investigations that used OCTA have increased exponentially in the past few years.

Imaging the anterior eye with dynamic-focus swept-source optical coherence tomography.

A custom-built dynamic-focus swept-source optical coherence tomography (SS-OCT) system with a central wavelength of 1310 nm was used to image the anterior eye from the cornea to the lens. An electrically tunable lens was utilized to dynamically control the positions of focusing planes over the imaging range of 10 mm. The B-scan images were acquired consecutively at the same position but with different focus settings.