Publications by authors named "Johnnie Lee"
Article Synopsis
- Integrase strand transfer inhibitor (InSTI)-based antiretroviral therapies can lead to increased weight gain in people with HIV, prompting the DEFINE study to explore if switching to a protease inhibitor (PI)-based regimen could reverse this trend.
- The study involved 103 adults who were either switched to a specific PI regimen (darunavir/cobicistat/emtricitabine/TAF) or continued their current treatment for the first half before the switch, with weight change measured primarily at 24 weeks.
- Results showed no significant weight change at 24 weeks between the two groups, but a potential trend toward weight loss was noted at 48 weeks, particularly in subgroups with higher weight gain risk, suggesting
Introduction: Integrase strand transfer inhibitor-based regimens (eg, containing dolutegravir [DTG]) are associated with weight/body mass index (BMI) increases among people living with HIV-1 (PLWH). Assessing antiretroviral therapy (ART)-related weight/BMI changes is challenging, as PLWH may experience return-to-health weight gain as a result of viral suppression. This retrospective, longitudinal real-world study compared weight/BMI outcomes among overweight/obese (BMI ≥25 kg/m; thus excluding return-to-health weight/BMI changes), treatment-naïve PLWH who initiated darunavir (DRV)/cobicistat (c)/emtricitabine (FTC)/tenofovir alafenamide (TAF) or DTG + FTC/TAF.
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- A significant change in the availability of antiretroviral therapies has allowed researchers to assess new second-line treatments for HIV-1 in low- and middle-income countries through the DEFT trial.
- The DEFT trial, initiated in 2017, compares a standard regimen of boosted darunavir with NRTIs to a newer NRTI-sparing regimen with boosted darunavir and dolutegravir.
- Arising from recent updates in treatment guidelines, the study decided to incorporate the evaluation of the TLD regimen as a third arm, instead of starting a new trial, to optimize resources and streamline recruitment.