Publications by authors named "Johnatan Alisson Oliveira Sousa"
5-Fluorouracil (5-FU) is an antimetabolite widely prescribed in cancer treatments, but its use in highly proliferative tissues can cause significant problems such as mucositis. is a probiotic commonly used for protection against acute diarrhea, gastrointestinal dysbiosis and inflammatory bowel diseases. We investigated the effect of on 5-FU intestinal mucositis in mice.
View Article and Find Full Text PDFEuterpe oleracea Mart. (Açaí) attenuates experimental colitis in rats: involvement of TLR4/COX-2/NF-ĸB.
Inflammopharmacology
February 2021
Euterpe oleracea Mart., commonly known as açaí, has been demonstrated to exhibit significantly antioxidant and inflammatory activities in experimental models. These effects of the hydroalcoholic extract from the açaí seed (ASE) were investigated in TNBS-induced (2,4,6-trinitrobenzenesulfonic acid) acute colitis model in rats.
View Article and Find Full Text PDFArticle Synopsis
- LASSBio-596 is a special medicine that helps reduce inflammation and protect the stomach from damage caused by alcohol.
- In an experiment, mice that were given LASSBio-596 before alcohol exposure had less stomach damage compared to those that didn't.
- The protective effects of LASSBio-596 are linked to a substance called nitric oxide, which helps it work better against stomach injuries.
Gastroprotective effects of N-acylarylhydrazone derivatives on ethanol-induced gastric lesions in mice are dependent on the NO/cGMP/K pathway.
Biochem Pharmacol
November 2019
The gastroprotective effects of N-acylarylhydrazone derivatives on ethanol-induced gastric lesions in mice were investigated with respect to the NO/cGMP/K pathway. To investigate our hypothesis, the mice were intraperitoneally pretreated with glibenclamide, L-NAME, or ODQ 30 min before treatment with DMSO, LASSBio-294 (1, 2, and 4 mg/kg, p.o.
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