Publications by authors named "John Wen-Chang Chang"
Article Synopsis
- A study was conducted to evaluate the effectiveness and safety of concurrent chemoradiotherapy (CCRT) using oral vinorelbine and cisplatin for treating stage III non-small cell lung cancer (NSCLC).
- The study included 58 patients and found a response rate of 53.4%, with a median progression-free survival of 6.73 months and overall survival of 24.83 months, indicating positive outcomes.
- No treatment-related deaths occurred, though neutropenia was the most common severe side effect observed in 18.9% of patients.
Background: In this study, we investigated the efficacy of continuous epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) administration in lung adenocarcinoma patients harboring favorable mutations regarding the progressive disease (PD) status with appearance of indolent new lesions.
Methods: From June 2010 to October 2012, 102 patients with lung adenocarcinoma, harboring favorable EGFR mutations and treated with EGFR-TKI were analyzed. Definite new lesions were detected during EGFR-TKI therapy, even though the primary target tumors were controlled.