Publications by authors named "John Wee Liang Kuan"
Human eyes absent (EYA) proteins possess Tyr phosphatase activity, which is critical for numerous cancer and metastasis promoting activities, making it an attractive target for cancer therapy. In this work, we demonstrate that the inhibitor-bound form of EYA2 does not favour binding to Mg , which is indispensable for the Tyr phosphatase activity. We further describe characterization and optimization of this class of allosteric inhibitors.
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- Researchers discovered small-molecule inhibitors that target EYA2's Tyr phosphatase activity, with one compound (NCGC00249987) binding to a specific site and altering the enzyme's conformation to inhibit its function.
- The study found that EYA2’s activity is crucial for lung cancer cell migration and invasion but not for growth, suggesting that NCGC00249987 could be a valuable tool for researching EYA2’s role and might lead to treatments for cancers dependent on this protein's activity.