Publications by authors named "John Watson Rutland"
Objective: Vascular structures may play a significant role in epileptic pathology. Although previous attempts to characterize vasculature relative to epileptogenic zones and hippocampal sclerosis have been inconsistent, an in vivo method of analysis would assist in resolving these inconsistencies and facilitate a comparison against healthy controls in a human model. Magnetic resonance imaging is a noninvasive technique that provides excellent soft tissue contrast, and the relatively recent development of susceptibility-weighted imaging has dramatically improved the visibility of small veins.
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- A study aimed to compare 7 Tesla (7T) MRI results in patients with focal epilepsy (who showed no lesions on standard scans) to those of healthy controls to improve understanding of their condition.* -
- Out of 37 epilepsy patients scanned, 25 showed potential issues related to seizures, with some findings directly linked to seizure onset zones, while others were not clearly connected.* -
- The high-resolution imaging from 7T MRI was crucial in identifying cortical lesions in epilepsy patients that regular MRI scans might miss, highlighting its potential for better diagnosis and treatment.*
Purpose: 7T (7T) magnetic resonance imaging (MRI) facilitates the visualization of the brain with resolution and contrast beyond what is available at conventional clinical field strengths, enabling improved detection and quantification of small structural features such as perivascular spaces (PVSs). The distribution of PVSs, detected in vivo at 7T, may act as a biomarker for the effects of epilepsy. In this work, we systematically quantify the PVSs in the brains of epilepsy patients and compare them to healthy controls.
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