Conductive Metal-Organic Frameworks and Their Electrocatalysis Applications.

Recently, electrically conductive metal-organic frameworks (EC-MOFs) have emerged as a wealthy library of porous frameworks with unique properties, allowing their use in diverse applications of energy conversion, including electrocatalysis. In this review, the electron conduction mechanisms in EC-MOFs are examined, while their electrical conductivities are considered. There have been various strategies to enhance the conductivities of MOFs including ligand modification, the incorporation of conducting materials, and the construction of multidimensional architectures.

Exosomes in review: A new frontier in CAR-T cell therapies.

Exosomes are extracellular vehicles that facilitate intra-cellular communication via transport of critical proteins and genetic material. Every exosome is intrinsically reflective of the cell from which it was derived and can even mimic effector functions of their parent cells. In recent years, with the success of CAR-T therapies, there has been growing interest in characterizing exosomes derived from CAR-T cells.

Durable response to treatment of an atypical desmoplastic small round cell tumor with enfortumab-vedotin.

Background: Desmoplastic small round cell tumor is a rare sarcoma type with poor prognosis for which there is no standard of care. It primarily affects adolescents and young adults and treatment is both multimodal and challenging due to the aggressive nature of the disease.

Case Presentation: we describe a case of a 27-year-old male who presented with hematuria and a five-centimeter mass on his bladder wall.

Dopamine D receptor antagonists alter autophosphorylation of focal adhesion kinases in the mouse forebrain in vivo.

Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase expressed in neurons of the developing and adult brain in addition to non-neuronal cells. Activation of FAK is initiated by autophosphorylation of the kinase at tyrosine 397 (Y397). Active FAK transmits extracellular signals inside neurons to integrate cytoskeletal rearrangements and modulate synaptic transmission and plasticity.

Aerial urination suggests undescribed sensory modality and social function in river dolphins.

Scent marking through urine spraying is known to aid mate selection, territory marking and chemical communication in terrestrial, but not in aquatic mammals. We quantify an unusual aerial urination behaviour in botos (Inia geoffrensis) and discuss its potential functions. Between 2014 and 2018, we conducted land-based behavioural surveys on wild botos in central Brazil, recording the sequence, duration and social context of aerial urination.

Immune-related adverse events not associated with survival in advanced or metastatic gastroesophageal cancers.

Immune checkpoint inhibitors (ICIs) have shown promise in the treatment of gastric and oesophageal cancers (GEC). Despite their promising efficacy, ICIs have been associated with unique side effects known as immune-related adverse events (IRAEs). Several studies have shown improved treatment responses in patients with IRAEs compared to those without IRAEs in various cancer types such as melanoma and non-small cell lung cancer.

Machine Learning-Assisted High-Donor-Number Electrolyte Additive Screening toward Construction of Dendrite-Free Aqueous Zinc-Ion Batteries.

The utilization of electrolyte additives has been regarded as an efficient strategy to construct dendrite-free aqueous zinc-ion batteries (AZIBs). However, the blurry screening criteria and time-consuming experimental tests inevitably restrict the application prospect of the electrolyte additive strategy. With the rise of artificial intelligence technology, machine learning (ML) provides an avenue to promote upgrading of energy storage devices.

Discovery and characterization of stereodefined PMO-gapmers targeting tau.

Antisense oligonucleotides (ASOs) are an important class of therapeutics to treat genetic diseases, and expansion of this modality to neurodegenerative disorders has been an active area of research. To realize chronic administration of ASO therapeutics to treat neurodegenerative diseases, new chemical modifications that improve activity and safety profiles are still needed. Furthermore, it is highly desirable to develop a single stereopure ASO with a defined activity and safety profile to avoid any efficacy and safety concerns due to the batch-to-batch variation in the composition of diastereomers.

2D Vertically Conductive Metal─Organic Framework Electrolytes: Will They Outperform 3D MOFs for Solid State Batteries?

Lithium-ion batteries are currently the mainstream for almost all portables, and quickly expand in electrical vehicles and grid storage applications. However, they are challenged by the poor safety regarding organic liquid electrolytes and relatively low energy density. Solid-state batteries, characterized by using solid-state electrolytes (SSEs), are recognized as the next-generation energy technology, owing to their intrinsically high safety and potentially superior energy density.

2D Conjugated Metal-Organic Frameworks for New Generation Flexible Multicolor Electrochromic Devices.

There has been considerable interest in 2D conductive conjugated MOFs (2D c-MOFs) for their potential applications in sensors, opto-electronics, catalysis, and energy storage, owing to their ultra-high specific surface area, relatively high electrical conductivity, and tunable pore channel sizes for ion/charge diffusion/adsorption. The unique advantages brought by systematic tunings in the metal nodes and organic ligands enable the creation of highly accessible and remarkable structures with diverse chemical and physical behaviors. While the 2D c-MOFs are being explored for the rapid widening spectrum of applications, in this work, the great potential of multicolor transitions and functional properties of these 2D c-MOFs are examined for the new generation of flexible multicolor electrochromic devices (FMEDs).

Leveraging diverse genomic data to guide equitable carrier screening: Insights from gnomAD v.4.1.0.

Analysis of exome data from the latest release of the Genome Aggregation Database (gnomAD v.4.1.

The crystal and cryo-EM structures of PLCγ2 reveal dynamic interdomain recognitions in autoinhibition.

Phospholipase C gamma 2 (PLCγ2) plays important roles in cell signaling downstream of various membrane receptors. PLCγ2 contains a multidomain inhibitory region critical for its regulation, while it has remained unclear how these domains contribute to PLCγ2 activity modulation. Here we determined three structures of human PLCγ2 in autoinhibited states, which reveal dynamic interactions at the autoinhibition interface, involving the conformational flexibility of the Src homology 3 (SH3) domain in the inhibitory region, and its previously unknown interaction with a carboxyl-terminal helical domain in the core region.

The Bacteria of a Fig Microcommunity.

Unlabelled: Understanding the biotic drivers of diversity is a major goal of microbial ecology. One approach towards tackling this issue is to interrogate relatively simple communities that are easy to observe and perturb. Figs (syconia) of the genus represent such a system.

Asymmetric Polarization Modulation of d-p Hybridization-Enhanced Bidirectional Sulfur Redox Kinetics with Heteronuclear Dual-Atom Catalysts.

Lithium sulfur batteries (LiSBs) represent a highly promising avenue for future energy storage systems, offering high energy density and eco-friendliness. However, the sluggish kinetics of the sulfur redox reaction (SRR) poses a significant challenge to their widespread applications. To tackle this challenge, we have developed an efficient heteronuclear dual-atom catalyst (hetero-DAC) that leverages surface charge polarization to enhance the asymmetric adsorption of sulfur intermediates.

Single-layer MoS/graphene-based stable on-chip Zn-ion microbattery for monolithically integrated electronics.

Self-powered microelectronics are essential for the sustained and autonomous operations of wireless electronics and microrobots. However, they are challenged by integratable microenergy supplies. Herein, we report a single-layer (SL) MoS/graphene heterostructure for stable Zn-ion microbatteries.

The Effects of Mechanical Loading on Resonant Response of a Conformal Load-Bearing Antenna System.

Glass fibre-reinforced polymer (GFRP) is a suitable substrate material for constructing a Conformal Load-Bearing Antenna Structure (CLAS). The relative permittivity of the CLAS substrate, which determines its resonant frequency, is affected by damage sustained by GFRP. This paper investigates the effects of damage (induced by mechanically loading the substrate) on the resonant response of the CLAS.

Surface Charge Regulation of Graphene by Fluorine and Chlorine Co-Doping for Constructing Ultra-Stable and Large Energy Density Micro-Supercapacitors.

Settling the structure stacking of graphene (G) nanosheets to maintain the high dispersity has been an intense issue to facilitate their practical application in the microelectronics-related devices. Herein, the co-doping of the highest electronegative fluorine (F) and large atomic radius chlorine (Cl) into G via a one-step electrochemical exfoliation protocol is engineered to actualize the ultralong cycling stability for flexible micro-supercapacitors (MSCs). Density functional theoretical calculations unveiled that the F into G can form the "ionic" C─F bond to increase the repulsive force between nanosheets, and the introduction of Cl can enlarge the layer spacing of G as well as increase active sites by accumulating the charge on pore defects.

In-Situ Polymerized High-Voltage Solid-State Lithium Metal Batteries with Dual-Reinforced Stable Interfaces.

Solid polymer electrolytes (SPEs) represent a pivotal advance toward high-energy solid-state lithium metal batteries. However, inadequate interfacial contact remains a significant bottleneck, impeding scalability and application. Inadequate interfacial contact remains a significant bottleneck, impeding scalability and application.