Publications by authors named "John Varthalitis"
Purpose: To evaluate the activity and tolerance of gemcitabine in combination with oxaliplatin (GEMOX regimen) in pretreated patients with advanced non-small cell lung cancer (NSCLC).
Patients And Methods: Thirty-two patients with advanced NSCLC who had disease progression after a cisplatin- and taxane-based front-line regimen were treated with gemcitabine (1500 mg/m(2) on days 1 and 8) and oxaliplatin (130 mg/m(2) on day 8) every 3 weeks. The patients' median age was 62 years and the performance status (WHO) was 0 for 11, 1 for 17 and 2 for 4 patients.
Purpose: To evaluate the efficacy and toxicity of the gemcitabine plus vinorelbine combination in pretreated patients with small cell lung cancer (SCLC).
Patients And Methods: Thirty-five pretreated patients (median age 59 years, PS: 0--1 in 97% and 2 in 3%) were treated with gemcitabine (1100 mg/m(2)) and vinorelbine (25mg/m(2)) on d1 and d8 every 3 weeks. Seven (20%) patients were treated with two prior regimens and 20 (57%) were refractory to front-line chemotherapy.
Article Synopsis
- - The study aimed to assess how effective and toxic the drug combination of irinotecan and gemcitabine is in patients with small-cell lung cancer who have previously undergone treatment.
- - Thirty-one patients were treated with specific doses of gemcitabine and irinotecan every 21 days, leading to a 10% overall response rate and 22% disease stabilization, with a median survival time of 6 months.
- - While the treatment showed limited effectiveness, it did not result in any toxic deaths and is suggested for further research in small-cell lung cancer patients who have already received chemotherapy.