Publications by authors named "John Van Antwerp"
Article Synopsis
- - Decarboxylation is a crucial process for transforming inactive cannabinoid acids in cannabis into active compounds like Δ-THC, CBD, and CBG, which are important for medical applications and require precise analytical methods for effective use.
- - The study examined the decarboxylation process at various temperatures (80°C to 145°C) over time using UHPSFC/PDA-MS, revealing that the reaction was first-order, with Δ-THC showing a faster reaction rate compared to CBD and CBG acids.
- - Results indicated that THCA-A decarboxylation was straightforward with no byproducts, while the decarboxylation of CBDA and CBGA faced complexities due to unexplained
Ultra-high-performance supercritical fluid chromatography (UHPSFC) is an efficient analytical technique and has not been fully employed for the analysis of cannabis. Here, a novel method was developed for the analysis of 30 cannabis plant extracts and preparations using UHPSFC/PDA-MS. Nine of the most abundant cannabinoids, viz.
View Article and Find Full Text PDFA new 'compact mass detector' co-developed with an instrument manufacturer (Waters Corporation) as an interface for liquid chromatography (LC), specifically Ultra-high performance LC(®) (UPLC(®) or UHPLC) analysis was evaluated as a potential new Open Access (OA) LC-MS platform in the Drug Discovery and Early Development space. This new compact mass detector based platform was envisioned to provide increased reliability and speed while exhibiting significant cost, noise, and footprint reductions. The new detector was evaluated in batch mode (typically 1-3 samples per run) to monitor reactions and check purity, as well as in High Throughput Screening (HTS) mode to run 24, 48, and 96 well plates.
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