Publications by authors named "John T Krall"

Background And Objectives: Paralysis after spinal cord injury involves damage to pathways that connect neurons in the brain to peripheral nerves in the limbs. Re-establishing this communication using neural interfaces has the potential to bridge the gap and restore upper extremity function to people with high tetraplegia. We report a novel approach for restoring upper extremity function using selective peripheral nerve stimulation controlled by intracortical microelectrode recordings from sensorimotor networks, along with restoration of tactile sensation of the hand using intracortical microstimulation.

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Article Synopsis
  • A novel approach to restore upper extremity function in individuals with high tetraplegia is explored through selective peripheral nerve stimulation, guided by signals from intracortical microelectrode recordings.
  • The study involved a right-handed man with complete paralysis due to spinal cord injury, who received implants in specific brain areas and peripheral nerves to enable targeted muscle contractions and restore tactile sensation.
  • Results showed successful recording of neural activity linked to intended movements and stimulation that allowed the subject to experience touch, indicating the system's effectiveness and good tolerance without complications.
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Unlabelled: Prediction of movement intentions from electromyographic (EMG) signals is typically performed with a pattern recognition approach, wherein a short dataframe of raw EMG is compressed into an instantaneous feature-encoding that is meaningful for classification. However, EMG signals are time-varying, implying that a frame-wise approach may not sufficiently incorporate temporal context into predictions, leading to erratic and unstable prediction behavior.

Objective: We demonstrate that sequential prediction models and, specifically, temporal convolutional networks are able to leverage useful temporal information from EMG to achieve superior predictive performance.

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