Frank H. Netter, M.D. (1906-1991): the artist and his legacy.

The renowned medical illustrator Frank H. Netter, M.D.

Comprehensive assessment of professional competence: the Rochester experiment.

Background: A required 2-week comprehensive assessment (CA) for 2nd-year medical students that integrates basic science, clinical skills, information management, and professionalism was implemented.

Description: The CA links standardized patients (SPs) with computer-based exercises, a teamwork exercise, and peer assessments; and culminates in student-generated learning plans.

Evaluation: Scores assigned by SPs showed acceptable interrater reliability.

Cyclooxygenase-2 modulates brain inflammation-related gene expression in central nervous system radiation injury.

Although the contribution of cyclooxygenase-2 (COX-2) to peripheral inflammation is well documented, little is known about its role in brain inflammation. For this purpose we studied COX-2 expression in the mouse brain following ionizing radiation in vivo, as well as in murine glial cell cultures in vitro. The possible role of COX-2 in modulating brain inflammation was examined utilizing NS-398, a COX-2 selective inhibitor.