Publications by authors named "John Stinson"
Article Synopsis
- - The study compares the efficacy of two treatments for moderate-to-severe atopic dermatitis: tralokinumab and dupilumab, both used with topical corticosteroids, without any direct head-to-head trials being conducted.
- - An indirect comparison analysis was performed using patient data from past trials, measuring improvements in various clinical response metrics at week 32, including Eczema Area and Severity Index (EASI) and quality of life assessments.
- - Results showed that both treatments had similar effectiveness overall; however, tralokinumab demonstrated a statistically significant greater improvement in the Dermatology Life Quality Index compared to dupilumab, indicating a preference for tralokinumab in enhancing quality of life.
Background: The management of hypertension is primarily performed in primary care settings in many health systems. However, two groups of patients often require specialist input: patients with resistant hypertension (RH) and young adults with hypertension.
Aims: To elucidate these groups by examining the characteristics of patients attending an Irish hypertension service, thus informing future management of hypertension.
The management of hypertension is suboptimal in Ireland and internationally. The role of a specialist hypertension clinic is not always defined but an analysis of the reasons for referral are likely informative. Also, a description of the clinical characteristics of patients with hypertension will inform requirements for comprehensive hypertension management in the community and secondary care.
View Article and Find Full Text PDFObjective: To examine the effects of low molecular weight heparins (LMWHs) on extravillous trophoblast (EVTC) invasiveness and on EVTC expression/secretion of heparin binding-EGF (HB-EGF) and cystein-rich angiogenic inducer 61 (Cyr61), both of which are involved in the process of EVTC invasion. Furthermore, to investigate the intracellular DNA binding activity of activator protein (AP)-1.
Design: Experimental study.
Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by vascular thrombosis and/or pregnancy morbidity in the presence of circulating antiphospholipid antibodies (aPL). Different pathogenic mechanisms for aPL-mediated pregnancy failure have been proposed. In particular a direct effect of aPL on both maternal and fetal side of the placental tissue has been reported, since their reactivity with β2-glycoprotein I (β2GPI) makes them adhere to trophoblast and human endometrial endothelial cell (HEEC) membranes.
View Article and Find Full Text PDFTinzaparin use in pregnancy: an international, retrospective study of the safety and efficacy profile.
Eur J Obstet Gynecol Reprod Biol
December 2011
Objectives: This study audited pregnancies where the mother received tinzaparin (at any stage before delivery), with a primary objective of determining the maternal safety of this low molecular weight heparin when administered as treatment and/or prophylaxis; the secondary objective was to audit fetal and neonatal safety in this cohort. Efficacy outcomes were also recorded.
Study Design: The audit period was 1996-2009; consecutive, retrospective pregnancy records at participating hospitals were reviewed.
Introduction: Trials comparing the use of full dose unfractionated heparin (UFH) or low molecular weight heparins (LMWHs) in very elderly patients with impaired renal function are lacking. IRIS aimed to assess whether LMWH is at least as safe as UFH in this population.
Materials And Methods: The study included renally impaired patients ≥70 years with acute symptomatic lower limb deep vein thrombosis (DVT).