Medical Information Delivering Improved Customer Experience: A Guide.

Customer experience (CX) is essential in any business. In the pharmaceutical industry, the Medical Information Contact Center is a customer-facing unit that provides evidence-based, scientifically balanced information to healthcare professionals and patients in response to unsolicited inquiries. The purpose of this paper is to provide analysis and guidance for designing and measuring interactions in the Medical Information Contact Center to facilitate the delivery of a superior and continuously improving CX.

Simulated practice effects on the transfer and retention of gait sequences from the upper to the lower extremity.

This study investigated transfer of training from upper extremity limbs (the index fingers) to the lower extremity limbs (the legs) for performance of three gait sequences of different difficulty. Fifteen subjects participated in the study. Subjects in an iPad training group practiced by sequentially moving their left-and right-hand index fingers across tiles to each of three targets displayed on an iPad for 20 trials.

Did Pleistocene Africans use the spearthrower-and-dart?

Archeologists commonly suppose that among complex projectile weapons humans use as subsistence aids, the spearthrower-and-dart preceded bow-and-arrow use. And yet, neither ethnographic nor archeological records furnish any robust evidence for spearthrower-and-dart use in Africa. Instead, evidence grows apace for ever-more ancient bow-and-arrow use.

Target position and avoidance margin effects on path planning in obstacle avoidance.

This study examined how people choose their path to a target, and the visual information they use for path planning. Participants avoided stepping outside an avoidance margin between a stationary obstacle and the edge of a walkway as they walked to a bookcase and picked up a target from different locations on a shelf. We provided an integrated explanation for path selection by combining avoidance margin, deviation angle, and distance to the obstacle.

Pupil diameter as a biomarker of effort in goal-directed gait.

Subjects' eye movement behavior related to cognitive effort during gait was measured as subjects walked to perform low and high cognitive load tasks. We found that all pupil diameter measures, fixation durations, and the proportion of blink duration changed significantly during gait as a function of task load. In contrast, the number of fixations, saccade durations and travel time did not change significantly as a function of task load.

Hierarchical goal effects on center of mass velocity and eye fixations during gait.

The purpose of this study was to determine the effect of hierarchical goal structure of a yet-to-be performed task on gait and eye fixation behavior while walking to the location of where the task was to be performed. Subjects performed different goal-directed tasks representing three hierarchical levels of planning. The first level of planning consisted of having the subject walk to a bookcase on which an object (a cup) was located in the middle of a shelf.

Knowledge vs. know-how? Dissecting the foundations of stone knapping skill.

Stone tools provide some of the best remaining evidence of behavioral change over long periods, but their cognitive and evolutionary implications remain poorly understood. Here, we contribute to a growing body of experimental research on the cognitive and perceptual-motor foundations of stone toolmaking skills by using a flake prediction paradigm to assess the relative importance of technological understanding vs. accurate action execution in Late Acheulean-style handaxe production.

Transcriptional Assessment of Striatal mRNAs as Valid Biomarkers of Disease Progression in Three Mouse Models of Huntington's Disease.

Background: Huntington's disease (HD) is a progressive neurodegenerative disorder that prominently affects the basal ganglia, leading to affective, cognitive, behavioral, and motor decline. The primary site of neuron loss in HD is the striatal part of the basal ganglia, with GABAergic medium size spiny neurons (MSNs) being nearly completely lost in advanced HD.

Objective: Based on the hypothesis that mutant huntingtin (mHTT) protein injures neurons via transcriptional dysregulation, we set out to establish a transcriptional profile of HD disease progression in the well characterized transgenic mouse model, R6/2, and two Knock-in models (KI); zQ175KI (expressing mutant mouse/human chimeric Htt protein) and HdhQ200 HET KI (carrying one allele of expanded mouse CAG repeats).

Organic Electrode Materials for Metal Ion Batteries.

Organic and polymer materials have been extensively investigated as electrode materials for rechargeable batteries because of the low cost, abundance, environmental benignity, and high sustainability. To date, organic electrode materials have been applied in a large variety of energy storage devices, including nonaqueous Li-ion, Na-ion, K-ion, dual-ion, multivalent-metal, aqueous, all-solid-state, and redox flow batteries, because of the universal properties of organic electrode materials. Moreover, some organic materials enable the batteries to be operated in the extreme conditions, such as a wide temperature range (-70 to 150 °C), a wide pH range, and in the presence of O.

How Older Adults Cope with Cognitive Complexity and Environmental Constraints during Dual-Task Walking: The Role of Executive Function Involvement.

This cross-sectional study investigated the interactive dual-task (DT) effects of executive function demands and environmental constraints on older adults' walking and the moderating role of habitual physical activity (PA). Locomotor performance under different environmental constraints (flat versus obstructed walking) and cognitive performance with different executive function involvement (backward counting versus random number generation) were assessed under single-task (ST) and DT conditions in 135 participants (mean age 68.1 ± 8.

Going big versus going small: Lithic miniaturization in hominin lithic technology.

Lithic miniaturization was one of our Pleistocene ancestors' more pervasive stone tool production strategies and it marks a key difference between human and non-human tool use. Frequently equated with "microlith" production, lithic miniaturization is a more complex, variable, and evolutionarily consequential phenomenon involving small backed tools, bladelets, small retouched tools, flakes, and small cores. In this review, we evaluate lithic miniaturization's various technological and functional elements.

Biomarker Analysis of Orally Dosed, Dual Active, Matrix Metalloproteinase (MMP)-2 and MMP-9 Inhibitor, AQU-118, in the Spinal Nerve Ligation (SNL) Rat Model of Neuropathic Pain.

There is an unmet medical need for the development of non-addicting pain therapeutics with enhanced efficacy and tolerability. The current study examined the effects of AQU-118, an orally active inhibitor of metalloproteinase-2 (MMP-2) and MMP-9, in the spinal nerve ligation (SNL) rat model of neuropathic pain. Mechanical allodynia and the levels of various biomarkers were examined within the dorsal root ganglion (DRG) before and after oral dosing with AQU-118.

A monumental cemetery built by eastern Africa's first herders near Lake Turkana, Kenya.

Monumental architecture is a prime indicator of social complexity, because it requires many people to build a conspicuous structure commemorating shared beliefs. Examining monumentality in different environmental and economic settings can reveal diverse reasons for people to form larger social units and express unity through architectural display. In multiple areas of Africa, monumentality developed as mobile herders created large cemeteries and practiced other forms of commemoration.

Occasional, obligatory, and habitual stone tool use in hominin evolution.

Archeologists have long assumed that earlier hominins were obligatory stone tool users. This assumption is deeply embedded in traditional ways of describing the lithic record. This paper argues that lithic evidence dating before 1.

Aging effect on step adjustments and stability control in visually perturbed gait initiation.

Gait adaptability is essential for fall avoidance during locomotion. It requires the ability to rapidly inhibit original motor planning, select and execute alternative motor commands, while also maintaining the stability of locomotion. This study investigated the aging effect on gait adaptability and dynamic stability control during a visually perturbed gait initiation task.

Steps to Health in Cognitive Aging: Effects of Physical Activity on Spatial Attention and Executive Control in the Elderly.

The purpose of this study was to investigate whether physical activity (PA) habits may positively impact performance of the orienting and executive control networks in community-dwelling aging individuals and diabetics, who are at risk of cognitive dysfunction. To this aim, we tested cross-sectionally whether age, ranging from late middle-age to old adulthood, and PA level independently or interactively predict different facets of the attentional performance. Hundred and thirty female and male individuals and 22 adults with type 2 diabetes aged 55-84 years were recruited and their daily PA (steps) was objectively measured by means of armband monitors.

Probing attention prioritization during dual-task step initiation: a novel method.

The present study investigated the attention allocation during reactive stepping using a continuous finger-tapping task. Ten healthy young subjects were recruited to participate in this study. Subjects were required to perform a rapid voluntary step with either left or right leg after hearing an auditory tone while tapping their right index finger on a handhold numeric keypad.

MOTOR IMAGERY, PHYSICAL PRACTICE, AND MEMORY: THE EFFECTS ON PERFORMANCE AND WORKLOAD.

-The theoretical explanations used to explain changes in performance during motor imagery and physical practice conditions are inconsistent when memory retrieval is and is not required. This study measured performance time and workload during acquisition, a retention test requiring memory retrieval, and a retention test not requiring memory retrieval using a key-pressing task. The participants were assigned to physical practice with or without instructions to learn or motor imagery with or without instructions to learn.

Early Upper Paleolithic chronology in the Levant: new ABOx-SC accelerator mass spectrometry results from the Mughr el-Hamamah Site, Jordan.

Methodological developments and new paleoanthropological data remain jointly central to clarifying the timing and systemic interrelationships between the Middle-Upper Paleolithic (MP-UP) archaeological transition and the broadly contemporaneous anatomically modern human-archaic biological turnover. In the recently discovered cave site of Mughr el-Hamamah, Jordan, in situ flint artifacts comprise a diagnostic early Upper Paleolithic (EUP) assemblage. Unusually well-preserved charcoal from hearths and other anthropogenic features associated with the lithic material were subjected to acid-base-wet oxidation-stepped combustion (ABOx-SC) pretreatment.

The posterior shift anticipatory postural adjustment in choice reaction step initiation.

The ability to step quickly in response to a perturbation has been shown to be critical for prevention of falls. The cognitive processing, weight shifting, and locomotion must be well timed to execute a successful step. The purpose of this study was to compare the response preparation and response execution processes between a simple (SRST) and a choice reaction stepping task (CRST).

Effects of mental practice in novice learners in a serial positioning skill acquisition.

The effects of mental practice in novices were investigated. University students (N = 60) performed a serial aiming task, distributed in 5 groups of 12: mental practice, physical practice, mental-physical practice (first mental then physical practice), physical-mental practice (first physical then mental practice), and a control group that only performed the tests. Participants transported three tennis balls among six containers in a pre-established sequence in a target time.

Effects of add-on nebivolol on blood pressure and glucose parameters in hypertensive patients with prediabetes.

In this multicenter trial, the effects of nebivolol added to an angiotensin-converting enzyme (ACE) inhibitor or angiotensin II receptor blocker (ARB) were assessed in patients with hypertension (diastolic blood pressure [DBP] 80-110 mm Hg) and prediabetes (fasting blood glucose 100-125 mg/dL and/or 2-hour oral glucose tolerance test [OGTT] 140-199 mg/dL). After a 4-week run-in period (in which lisinopril [10 mg/d] or losartan [50 mg/d] treatment was initiated), patients with DBP 90-110 mm Hg were randomized (2:2:1) to 12-week, double-blind treatment with nebivolol (n=223; 5-40 mg/d), hydrochlorothiazide (HCTZ; n=212; 12.5-25 mg/d), or placebo (n=102), titrated to achievement of 130/80 mm Hg.

A two process memory-based account for mental and physical practice differences.

The authors investigated the underlying processing structures for mental and physical practice. Participants mentally or physically performed 4 tasks during practice. Halfway through practice, 2 tasks were switched from mental to physical practice, or vice versa.