Publications by authors named "John Santoro"
MLL/KMT2A amplifications and translocations are prevalent in infant, adult, and therapy-induced leukemia. However, the molecular contributor(s) to these alterations are unclear. Here, we demonstrate that histone H3 lysine 9 mono- and di-methylation (H3K9me1/2) balance at the MLL/KMT2A locus regulates these amplifications and rearrangements.
View Article and Find Full Text PDFMethane Carboxylation Using Electrochemically Activated Carbon Dioxide.
Angew Chem Int Ed Engl
July 2023
Direct synthesis of CH COOH from CH and CO is an appealing approach for the utilization of two potent greenhouse gases that are notoriously difficult to activate. In this Communication, we report an integrated route to enable this reaction. Recognizing the thermodynamic stability of CO , our strategy sought to first activate CO to produce CO (through electrochemical CO reduction) and O (through water oxidation), followed by oxidative CH carbonylation catalyzed by Rh single atom catalysts supported on zeolite.
View Article and Find Full Text PDFBackground: Estimates suggest that only 20 % of HCV-infected patients have been identified and <10 % treated. However, baby boomers (1945-1965) are identified as having a higher prevalence of HCV which has led the Centers for Disease Control and Prevention to make screening recommendations. The aim of this study was to implement the CDC's screening recommendations in the unique setting of gastroenterology practices in patients previously unscreened for HCV.
View Article and Find Full Text PDFBackground: Massachusetts (MA) instituted a moratorium on ambulance diversion ("No Diversion") on January 1, 2009.
Study Objectives: Determine whether No Diversion was associated with changes in Emergency Department (ED) throughput measures.
Design: Comparison of three 3-month periods.
Background: Admitted and discharged patients with prolonged emergency department (ED) stays may contribute to crowding by utilizing beds and staff time that would otherwise be used for new patients.
Objectives: To describe patients who stay > 6 h in the ED and determine their association with measures of crowding.
Methods: This was a retrospective, observational study carried out over 1 year at a single, urban, academic ED.
Our purpose was to demonstrate the impact of changes in technology, staffing, and departmental processes on service levels in emergency department (ED) radiology. We also attempted to determine if report turnaround time affects ED patient throughput. Radiology performance was evaluated before and after the modifications of processes integral to the interpretation of ED imaging.
View Article and Find Full Text PDFUnlabelled: This prospective, multicenter, community-based and academic-based, open-label, investigator-initiated, U.S. study evaluated efficacy and safety of pegylated interferon (PEG-IFN) alfa-2b plus a flat or weight-based dose of ribavirin (RBV) in adults with chronic hepatitis C.
View Article and Find Full Text PDFAchieving an antiviral response at a reasonable cost is a challenge in the treatment of patients with chronic hepatitis C. A previous study indicated that consensus interferon with ribavirin had promising activity against hepatitis C virus (HCV) genotype 1. The objective of this study was to determine the virologic response with consensus interferon or pegylated interferon alpha-2b plus weight-ribavirin in patients chronically infected with HCV genotype 1.
View Article and Find Full Text PDFIntroduction: Emergency department (ED) overcrowding has been a significant problem for the last 10 years. Several studies have shown that a relatively small number of ED patients are responsible for a disproportionate amount of ED visits. This study aims to describe the frequent users of our emergency department.
View Article and Find Full Text PDF