Publications by authors named "John Santa Kumar"
Background: Gallium-68-prostate-specific membrane antigen (Ga-PSMA) positron emission tomography/computed tomography (PET/CT) has recently been shown to be very high accuracy in biopsy-naïve prostate cancer (PCa) detection and can potentially improve the low specificity noted with diffusion-weighted magnetic resonance imaging (DW-MRI), especially in instances of prostate inflammation. We aimed to compare the diagnostic accuracy of DW-MRI and PSMA PET/CT using apparent diffusion coefficient (ADC) and maximum standardized uptake (SUV) values in the diagnosis of PCa.
Patients And Methods: A retrospective study comparing and analyzing the diagnostic accuracy of prebiopsy DW-MRI and Ga-PSMA PET/CTs done in patients with suspected PCa (raised prostate specific antigen [PSA] and/or positive digital rectal examination) from January 2019 to December 2020.
Article Synopsis
- The study aimed to evaluate the effectiveness of Ga-68 PSMA PET/CT scans in detecting prostate cancer (PCa) in patients with serum PSA levels under 50 ng/ml, due to the low predictive value of current biopsy methods.
- A retrospective analysis was conducted on 64 patients suspected of PCa, comparing PSMA PET/CT results to traditional 12-core TRUS-guided biopsies for diagnostic performance.
- The PSMA PET/CT showed promising results with 74% sensitivity and 92% specificity, indicating it could be a more reliable tool for detecting PCa compared to standard methods, especially at higher PSA levels and Gleason scores.