Effect of Long-Term Hormonal Therapy (vs Short-Term Hormonal Therapy): A Secondary Analysis of Intermediate-Risk Prostate Cancer Patients Treated on NRG Oncology RTOG 9202.

Purpose: NRG Oncology RTOG 9202 was a randomized trial testing long-term adjuvant androgen deprivation (LTAD) versus initial androgen deprivation only (STAD) with external beam radiation therapy (RT) in mostly high-risk and some intermediate-risk prostate cancer patients. RTOG 9408 found an overall survival (OS) advantage in patients with cT1b-T2b disease and prostate-specific antigen (PSA) <20 ng/mL, with benefit observed mostly among intermediate-risk patients. It was still unknown whether intermediate-risk patients would experience an additional survival benefit with LTAD; thus, we performed a secondary analysis to explore whether LTAD had any incremental benefit beyond STAD among the intermediate-risk subset of RTOG 9202.

Adjuvant carboplatin and paclitaxel chemotherapy interposed with involved field radiation for advanced endometrial cancer.

Objective: To evaluate recurrence and survival associated with adjuvant carboplatin and paclitaxel chemotherapy interposed with involved field radiation for advanced endometrial cancer.

Method: This is a prospective cohort study of women with Stage III and IV endometrial cancer treated at a single institution between April 2002 and July 2006. Adjuvant therapy consisted of 4 cycles of intravenous paclitaxel (175 mg/m(2)) and carboplatin (350 mg/m(2)) every 3 weeks, followed by external beam radiotherapy (RT) to the pelvis (45 Gy), then another 2 cycles of chemotherapy.

Optimization of high-dose-rate cervix brachytherapy applicator placement: the benefits of intraoperative ultrasound guidance.

Purpose: To promote efficient workflow for image-guided high-dose-rate (HDR) brachytherapy (BT) for cervix cancer by implementing intraoperative ultrasound (US) guidance for placement and optimization of intrauterine applicators. We sought to establish this as part of routine radiation oncology practice without radiology consultation.

Methods And Materials: Thirty-five consecutive insertions were performed in 21 women between July 2006 and March 2007.

Brain metastases from endometrial carcinoma: a retrospective study.

Objective: The objective of this study was to examine the characteristics and treatment results of patients at our center with brain metastases from endometrial carcinoma.

Methods: Between January 1991 and March 2003, there were 1295 women referred to the London Regional Cancer Centre with the diagnosis of endometrial cancer, and eight of these women (0.6%) developed brain metastases.