Publications by authors named "John Randall Clayton"
Proc Natl Acad Sci U S A
August 2005
Article Synopsis
- The malaria vector Anopheles gambiae uses REL2, an NF-kappaB-like transcription factor, to regulate the expression of the antimicrobial peptide Cecropin 1.
- Through alternative splicing, REL2 produces two protein isoforms: a full-length (REL2-F) and a shorter version (REL2-S), with different roles in immune response against bacteria.
- REL2-F also plays a role in regulating infection severity by the malaria parasite Plasmodium berghei and is involved in the regulation of at least 10 other immune-related genes.
