Transoral laser microsurgery as primary treatment for advanced-stage oropharyngeal cancer: a United States multicenter study.

Background: Nonsurgical modalities are sometimes advocated as the standard of care for advanced oropharyngeal tumors. Oncologic and functional results have been modest. The aim of our study was to evaluate outcomes of a minimally invasive approach, using transoral laser microsurgery (TLM) as the primary treatment for advanced oropharyngeal carcinoma.

Functional and manofluorographic outcomes after transoral endoscopic pharyngoesophageal diverticulostomy.

Objectives: To investigate functional and manofluorographic findings of patients with pharyngoesophageal diverticulum before and after transoral endoscopic pharyngoesophageal diverticulostomy (TEPD) and to comment on outcomes relative to predictors of successful treatment and pathogenesis of pharyngoesophageal diverticulum.

Design: Retrospective medical record review.

Setting: Academic center.

Manofluorographic and functional outcomes after endoscopic laser cricopharyngeal myotomy for cricopharyngeal bar.

Objective: To investigate the manofluorographic and functional outcomes after endoscopic laser cricopharyngeal myotomy (ELCPM) for cricopharyngeal (CP) bar.

Study Design: Case series with chart review.

Setting: Academic medical center.

Transoral laser microsurgery for early laryngeal cancer.

The decision to treat patients suffering from glottic cancer with either radiotherapy or surgery is both complex and controversial. Transoral laser microsurgery is a surgical technique that offers an attractive alternative therapy for laryngeal cancer. In addition to excellent oncologic outcomes and organ preservation, the benefits of transoral laser microsurgery include low morbidity and mortality, shorter periods of hospitalization and exceptional functional results.

Anterior cervical osteophyte dysphagia: manofluorographic and functional outcomes after surgery.

Background: Our aim was to investigate the clinical and manofluorographic findings of patients with anterior cervical osteophyte (ACO) dysphagia before and after surgery.

Methods: Chart review including manofluorography (MFG) data of patients undergoing ACO removal was undertaken.

Results: Thirteen patients underwent transcervical ACO removal over a 10-year period.

Computed tomographic angiography with three-dimensional reconstruction for transoral laser microsurgery.

Objective: To identify major arteries in relationship to large pharyngeal tumors during transoral laser microsurgery.

Study Design: Case series with planned data collection.

Setting: Mayo Clinic, Jacksonville, Florida.

Love and fear of heights: the pathophysiology and psychology of height imbalance.

Individual psychological responses to heights vary on a continuum from acrophobia to height intolerance, height tolerance, and height enjoyment. This paper reviews the English literature and summarizes the physiologic and psychological factors that generate different responses to heights while standing still in a static or motionless environment. Perceptual cues to height arise from vision.

Oropharyngeal cancer: a case for single modality treatment with transoral laser microsurgery.

Objective: To demonstrate the role of transoral laser microsurgery (TLM) in the treatment of oropharyngeal cancer.

Design: A 2-center retrospective case series analysis.

Setting: Two tertiary care medical centers.

Total laryngectomy in patients with advanced bulbar symptoms of amyotrophic lateral sclerosis.

Our objectives were to 1) increase awareness of total laryngectomy (TL) as a treatment for complications of bulbar weakness in patients with amyotrophic lateral sclerosis (ALS) and outline specific surgical indications; 2) educate physicians about the surgical procedure, peri-operative course and benefits from having a TL; and 3) retrospectively review the clinical course of Mayo Clinic-Florida patients with ALS who had a TL. The method used was a retrospective review of patients recommended to undergo TL for advanced bulbar symptoms related to ALS at the Mayo Clinic in Jacksonville, Florida. Between January 1999 and September 2008, 15 patients with severe bulbar symptoms associated with ALS were recommended to undergo TL.

Postoperative bleeding in transoral laser microsurgery for upper aerodigestive tract tumors.

Objectives: To report the incidence, cause, and outcome of bleeding after transoral laser microsurgery.

Study Design: A two-center prospective case series analysis.

Subjects And Methods: Seven hundred one patients underwent transoral laser microsurgery for tumors of the oral cavity, pharynx, and larynx from June 1996 through September 2006.

Transoral laser microsurgery for recurrent laryngeal and pharyngeal cancer.

Study Design And Setting: A two-center prospective case series analysis.

Patients: One hundred fourteen patients with previously treated laryngeal or pharyngeal squamous cell carcinoma who underwent salvage transoral laser microsurgery (TLM).

Interventions: TLM in 114 patients, neck dissection in 22 (19%) patients, adjuvant radiotherapy in 12 (11%) patients.

Transoral laser microsurgery for advanced laryngeal cancer.

Objective: To report the oncologic and functional outcomes of transoral laser microsurgery (TLM) in the treatment of advanced laryngeal cancer.

Design: Prospective case series study.

Setting: Multi-institution (academic, tertiary referral centers).

Transoral laser microsurgery for untreated glottic carcinoma.

Objectives: To report the oncology and functional outcomes of transoral laser microsurgery (TLM) for untreated glottic carcinoma.

Study Design: A 2 center prospective case series analysis.

Setting: Academic, tertiary referral centers.

Transoral laser microsurgery for carcinoma of the supraglottic larynx.

Objectives: The study goal was to report the oncologic outcomes of transoral laser microsurgery (TLM) in the treatment of squamous cell carcinoma of the supraglottic larynx.

Study Design And Setting: A two-center prospective case series analysis.

Results: Thirty-eight patients underwent TLM for previously untreated carcinoma of the supraglottic larynx between 1997 and 2005.

Carcinoma of the tongue base treated by transoral laser microsurgery, part two: Persistent, recurrent and second primary tumors.

Objectives: To report the oncologic and functional outcomes of transoral laser microsurgery (TLM) in the treatment of persistent, recurrent, and second primary squamous cell carcinoma of the tongue base.

Study Design: A two-center prospective case series analysis.

Methods: Twenty-five patients with persistent, recurrent, or second primary squamous cell carcinoma of the tongue base were treated with TLM between 1997 and 2005.

Carcinoma of the tongue base treated by transoral laser microsurgery, part one: Untreated tumors, a prospective analysis of oncologic and functional outcomes.

Objectives: To report the oncologic and functional outcomes of transoral laser microsurgery (TLM) in the management of untreated primary carcinoma of the tongue base.

Study Design: A two center prospective case series analysis.

Methods: Fifty-nine patients with pathologically confirmed squamous cell carcinoma of the tongue base were treated with TLM between 1997 and 2005.

Transoral laser microresection for cancer of the larynx involving the anterior commissure.

Objective: To share the authors' experience of transoral laser microresection in the treatment of squamous cell carcinoma of the anterior commissure of the larynx.

Study Design: Retrospective review of 39 patients with squamous carcinoma involving the anterior commissure of the larynx, all managed with transoral laser microresection between September 1996 and December 2001. Twenty-three patients had pT1 or pT2 cancers.

Comparison of methods for determining cricopharyngeal intrabolus pressure in normal patients as possible indicator for cricopharyngeal myotomy.

Objective: We sought to compare methods for determining intrabolus cricopharyngeal pressure as a possible indicator for cricopharyngeal myotomy.

Study Design: We determined multiple intrabolus pressures in the cricopharyngeal region of 20 normal volunteers, of whom 12 were 20 to 35 years old and 8 were older than 75 years. Data were collected using a commercially available manofluorography system and a 6-sensor unidirectional solid-state 2- x 4-mm catheter.