Nitrofurantoin-Induced Granulomatous Interstitial Pneumonia.

Nitrofurantoin-induced lung toxicity is relatively common, but rare histologic patterns sometimes occur that may make diagnosis difficult. We present the case of a 69-year-old woman taking prophylactic nitrofurantoin for urinary tract infections, who developed granulomatous interstitial pneumonia. She improved with cessation of nitrofurantoin, without other therapy.

The enhancing rim: a new sign of a benign pulmonary nodule.

Objective: To describe a new radiological sign, the enhancing rim sign, that indicates that a solitary pulmonary nodule is benign rather than malignant.

Patients And Methods: Sixteen adult patients underwent computed tomographic (CT) evaluation with intravenous contrast enhancement of an indeterminate solitary pulmonary nodule between May 25, 2000, and March 21, 2002, at the Mayo Clinic in Scottsdale, Ariz. In each patient, we identified a rim of enhancing soft tissue at the periphery of a solitary pulmonary nodule; this rim surrounds a homogeneous, lower-density central portion of the nodule.

Upper lobe pulmonary fibrosis associated with high-dose chemotherapy containing BCNU for bone marrow transplantation.

Upper lobe fibrotic lung disease is most often associated with sarcoidosis, Langerhans cell histiocytosis, silicosis, and other pneumoconioses but is usually not associated with drug-induced lung disease. Carmustine (BCNU) is a chemotherapeutic agent known to cause pulmonary toxicity. The radiographic pattern is usually diffuse bilateral lung disease predominantly in the lung bases.