Publications by authors named "John Paul Killen"
Article Synopsis
- IgA nephropathy (IgAN) and minimal change disease (MCD) are the most frequently reported glomerular diseases following COVID-19 vaccinations, especially mRNA vaccines, along with others like membranous nephropathy.
- A global registry was created to collect anonymized data on patients with glomerular diseases suspected after vaccination, focusing on vaccination details, kidney function, and treatment outcomes.
- Results show that while IgAN and MCD have a better chance of kidney function recovery and reduced proteinuria within 4–6 months post-vaccination, causality remains unproven despite a temporal link.
We report an unusual case of fibrillary glomerulonephritis (FGN) presenting as rapidly progressive renal failure and extensive crescent formation along with linear staining of capillary walls of the glomeruli on immunofluorescence, mimicking anti-glomerular basement membrane (anti-GBM) antibody-mediated disease. Laboratory results for circulating anti-GBM antibodies were negative. The subsequent electron microscopic findings were that of presence of electron-dense deposits in the glomerular mesangium and capillary walls, comprising of non-branching fibrils with an average diameter of 16 nm consistent with a diagnosis of FGN.
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