Publications by authors named "John Paul Haydek"
World J Hepatol
March 2019
Article Synopsis
- Sickle cell disease (SCD) increases the risk of hospitalizations and mortality, and the study focuses on a complication called sickle cell hepatopathy (SCH), specifically extreme hyperbilirubinemia (EH).
- The aim is to determine how EH affects morbidity and mortality in patients with SCD, using data from a retrospective cohort study at Grady Memorial Hospital.
- The study found that 4.8% of patients had severe EH, with significant differences in genotypes, revealing that those with hemoglobin SS are more likely to experience EH and higher liver enzyme levels.
Am J Transplant
October 2018
Article Synopsis
- Interferon treatment for hepatitis C in liver transplant recipients can lead to immune-mediated graft dysfunction (IGD), with low occurrence rates during direct-acting antiviral (DAA) therapy, reported at 3.4% in a study of HCV+LT patients.
- The study revealed that IGD typically emerged after DAA treatment completion, and many patients exhibited liver enzyme elevations, which were linked to subsequent IGD.
- While IGD is rare, early diagnosis and treatment are essential, as patients with IGD experienced higher rates of complications such as hospitalizations and infections compared to controls.
