Publications by authors named "John P Utsey"
Management of High-Throughput DNA Sequencing Projects: Alpheus.
J Comput Sci Syst Biol
December 2008
Article Synopsis
- High-throughput DNA sequencing has revolutionized systems biology, enhancing research in health, agriculture, and basic biology by allowing for the analysis of large volumes of complex data.
- Alpheus is a specialized software tool designed to analyze DNA sequencing data from various technologies, helping researchers align sequences, detect genetic variants, and measure expression levels effectively.
- The software improves variant detection by filtering calls based on factors like consistency and quality, and allows for comparative analysis between different samples, making it valuable for research in genetics and genomics.
Schizophrenia (SCZ) is a common, disabling mental illness with high heritability but complex, poorly understood genetic etiology. As the first phase of a genomic convergence analysis of SCZ, we generated 16.7 billion nucleotides of short read, shotgun sequences of cDNA from post-mortem cerebellar cortices of 14 patients and six, matched controls.
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