Publications by authors named "John P Fitzgerald"
For organ-confined prostate cancer, socioeconomic factors influencing Magnetic Resonance Imaging (MRI)-guided biopsy utilization and downstream prostate cancer patients' care are unknown. This retrospective, observational cohort study used the New York Statewide Planning and Research Cooperative System (SPARCS) billing-code driven database to examine the impact of prostate patients' socioeconomic characteristics on prostate cancer care defined as initial biopsy, 2-month post-biopsy cancer diagnoses, and within 1-year cancer-related intervention, controlling for other risk factors. From 2011-2017, the population studied (n = 18,253) included all New York State-based, male, residents aged 18 to 75 without a prior prostatectomy receiving a first-time biopsy; 760 such patient records in 2016 were removed due to data quality concerns.
View Article and Find Full Text PDFThere is a clinical need to identify novel biomarkers to improve diagnostic accuracy for the detection of urothelial tumors. The current study aimed to evaluate keratin 17 (K17), an oncoprotein that drives cell cycle progression in cancers of multiple anatomic sites, as a diagnostic biomarker of urothelial neoplasia in bladder biopsies and in urine cytology specimens. We evaluated K17 expression by immunohistochemistry in formalin-fixed, paraffin embedded tissue specimens of non-papillary invasive urothelial carcinoma (UC) (classical histological cases), high grade papillary UC (PUC-LG), low grade papillary UC (PUC-HG), papillary urothelial neoplasia of low malignant potential (PUNLMP), and normal bladder mucosa.
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- The study looked at how the number of lymph nodes (LNs) examined during surgery affects the recovery of patients with bladder cancer who don’t have cancer in their lymph nodes.
- Researchers analyzed data from over 4,188 patients, focusing on about 3,088 who had no cancer spread to their LNs.
- They found that more examined LNs (especially 20 or more) were linked to better chances of staying cancer-free, but for some patients with advanced cancer, this link wasn't as strong, suggesting more research is needed for optimal treatment.
Article Synopsis
- Researchers found that certain proteins called cytokines, which are linked to inflammation, are high in patients with a type of cancer called renal cell carcinoma (RCC), and this is not good for survival.
- They discovered that RCC cells produce two specific cytokines, IL-6 and IL-8, when there is low oxygen, and a protein named Nox4 helps with this process.
- The study suggests that by activating another protein called AMPK, it might be possible to reduce the harmful effects of these cytokines and slow down the spread of RCC, making it a potential target for new treatments.
The basis of treatment for advanced germ cell tumors is chemotherapy and surgical resection of residual disease. Surgery has maintained its role in staging and therapeutic management. Despite these advances, much of the outcomes depend on proper patient selection.
View Article and Find Full Text PDFPurpose: Tubulointerstitial fibrosis, the histological feature of chronic obstructive nephropathy, is delineated in complete unilateral ureteral obstruction models. Histological changes during chronic partial ureteral obstruction are not well studied. We describe changes in a rat model of partial ureteral obstruction.
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- Different personal and organization factors affect how people feel about using naltrexone, methadone, and buprenorphine to treat alcohol and drug problems.
- Research showed that individual factors had a bigger impact on attitudes than organizational factors.
- A specific factor, support for psychiatric medications, played a key role in shaping attitudes about all three medications.