Different Endocrine Effects of an Evening Dose of Amitriptyline, Escitalopram, and Placebo in Healthy Participants.

Objective: The primary aim of this study was to further characterize the acute effects of amitriptyline (AMI) and escitalopram (ESC) on serum levels of ghrelin, leptin, cortisol and prolactin in healthy humans.

Methods: Eleven healthy male participants received a single dose of AMI 75 mg, ESC 10 mg, or placebo (PLA) at 9:00 PM in a double blind, randomized, controlled, repeated measures study separated by one week. Fasting morning serum levels (7:00 AM) of ghrelin, leptin, cortisol and prolactin were assessed.

Myoclonic Jerks and Schizophreniform Syndrome: Case Report and Literature Review.

Schizophreniform syndromes can be divided into primary idiopathic forms as well as different secondary organic subgroups (e.g., paraepileptic, epileptic, immunological, or degenerative).

Sleep restriction over several days does not affect long-term recall of declarative and procedural memories in adolescents.

Objectives: There is broad evidence that sleep as opposed to waking facilitates the consolidation of both declarative and procedural memory. The current study addressed the question whether different extents of sleep restriction after learning would impair long-term memory consolidation in adolescents.

Methods: Eighty-eight healthy adolescents were randomized to five different sleep protocols with 9, 8, 7, 6 or 5 h of time in bed for four consecutive nights under controlled conditions that excluded daytime sleep.

[Insomnia].

Insomnia is a highly prevalent disorder with consequences for the patient's physical and mental health, daily function, and job performance. This paper gives an overview on current and new pharmacological treatments of insomnia. Additionally, some evidence based treatment options with regard to cognitive behavioral therapy are presented.