Evaluation of two novel plant gums for bioadhesive microsphere and sustained-release formulations of metformin hydrochloride.

Background: The biological half life of metformin requires multiple doses which are associated with poor patient compliance. This justifies the need for a dosage form with reduced dosing frequency.

Objectives: Gums from Enterolobium cyclocarpum and Cedrela odorata trees were evaluated in formulating bioadhesive microspheres containing metformin hydrochloride, for sustained drug release.

Evaluation of highly branched cyclic dextrin in inhalable particles of combined antibiotics for the pulmonary delivery of anti-tuberculosis drugs.

This work aims to identify a suitable formulation for the pulmonary delivery of combinations of inhalational drugs using highly branched cyclic dextrin (HBCD) macromolecules. We compared the effectiveness between powders prepared from HBCD with those prepared from five alternative excipients (lactose, maltose, sucrose, β-cyclodextrin and methyl β-cyclodextrin) in the pulmonary delivery of a single-dosage form of two anti-tuberculosis drugs (isoniazid and rifampicin). Fine particles of untreated active pharmaceutical ingredients (APIs) and combination products using excipients were prepared by spray drying.

Formulation and Evaluation of Oral Dissolving Films of Amlodipine Besylate Using Blends of Starches With Hydroxypropyl Methyl Cellulose.

Background: Natural polymers serve as cheap, non-toxic, biocompatible excipients in oral drug delivery. These advantages inform their uses in the design of drug dosage forms.

Objectives: The aim of the study was to prepare and evaluate oral dissolving films of amlodipine besylate, an anti-hypertensive drug, using starch/polymer blends.

Effects of excipients and formulation types on compressional properties of diclofenac.

Different models used to characterize powders have not been extended to granule behavior in tablet technology. Hence, Kawakaita equation and tapping experiments were used to compare the effect of different excipients on the properties of powders and granules in diclofenac formulations containing corn starch (DCS), lactose (DL) and dicalcium phosphate (DDCP). The binding properties of Albizia gum from Albizia zygia tree were also compared with those of gelatin in the granule formulations.