Publications by authors named "John Oishi"
Background: Clinicians often use population-based reference intervals (RIs) when interpreting patient results. However, this method can present problems if the analyte in question has wide variability from person to person.
Methods: We examined the biological variation of routine hematologic markers in 82 white non-Hispanic men every 6 months during a 30-year period, to determine the usefulness of population-based RIs and age-related decline of hematological markers.
Article Synopsis
- Protective MHC-I alleles like B*57 and B*27 enhance long-term control of HIV-1, primarily through the CD8 cytotoxic-T-lymphocyte (CTL) response.
- The study integrates advanced fitness profiling of HIV-1 Gag mutations, MHC-peptide binding predictions, and virus evolution analysis to examine how protective and nonprotective MHC-I alleles differ in terms of CTL escape mutations.
- Results indicate that mutations in protective MHC-I alleles incur higher fitness costs and smaller reductions in MHC-I binding affinity, which helps explain their superior viral control and may guide the development of HIV functional cures.
Acute HIV-1 seroconversion with an unusual plasma biomarker profile.
Clin Vaccine Immunol
November 2013
An unusual case of acute primary HIV-1 infection in a man with a high plasma viral load, a 51-fold increase in C-reactive protein, and antibodies against only gp160 is described. Numerous serum cytokine concentrations were elevated during HIV-1 seroconversion.
View Article and Find Full Text PDF