Elsberg Syndrome: An Overlooked But Treatable Cause of Back Pain.

Introduction: Elsberg syndrome is an uncommon cause of lumbosacral radiculitis that presents as a constellation of symptoms, including urinary retention, bowel incontinence, severe constipation, impotence, and saddle anesthesia.

Case Presentation: A 32-year-old female presented to the emergency department with complaints of bilateral leg pain and urinary retention. Two weeks prior, she noticed new genital lesions and had a positive nucleic acid amplification test for herpes simplex virus (HSV) type 2.

Extensive Invasive Sinusitis Secondary to Infection.

Invasive sinusitis is a rare complication of sinusitis. We present the case of a woman, age 72 years, who presented with acute encephalopathy in the setting of sepsis found to have extensive invasive sinusitis with intracranial extension secondary to , managed with intravenous antibiotics alone. is a rare cause of acute bacterial sinusitis, associated with infections of relatively greater severity and risk of intracranial spread, often requiring a combination of intravenous antibiotics and surgical debridement for source control.

Left atrial appendage structural characteristics predict thrombus formation.

Introduction: Nonvalvular atrial fibrillation (NVAF) is a highly prevalent arrhythmia where loss of synchronized atrial contraction increases the risk of intracardiac thrombus particularly within the left atrial appendage (LAA). Anticoagulation is the mainstay of stroke prevention based on the CHA DS -VASc score; however, it does not account for LAA structural characteristics.

Methods: The research comprises a retrospective matched case-control study of 196 subjects with NVAF who underwent transesophageal echo (TEE).

Oncolytic vaccinia virus reinvigorates peritoneal immunity and cooperates with immune checkpoint inhibitor to suppress peritoneal carcinomatosis in colon cancer.

Background: Peritoneal carcinomatosis (PC) is a common and devastating manifestation of colon cancer and refractory to conventional anticancer therapeutics. During the peritoneal dissemination of colon cancer, peritoneal immunity is nullified by various mechanisms of immune evasion. Here, we employed the armed oncolytic vaccinia virus mJX-594 (JX) to rejuvenate the peritoneal antitumor immune responses in the treatment of PC.

A Rare Complication of HVAD Outflow Thrombosis and the Importance of HVAD Waveform Analysis.

We present a case of a 64-year-old female who was supported with an HVAD as bridge-to-transplant (BTT) who presented with a gastrointestinal (GI) bleeding and underwent esophagogastroduodenoscopy (EGD) and colonoscopy. Her waveforms changed abruptly following the procedure, and she decompensated. With various imaging modalities and hemodynamic monitoring, we felt that she had thrombus in her outflow graft, which improved following systemic heparinization.

Suspensions for intravenous (IV) injection: a review of development, preclinical and clinical aspects.

There has been growing interest in nanoparticles as an approach to formulate poorly soluble drugs. Besides enhanced dissolution rates, and thereby, improved bioavailability, nanoparticles can also provide targeting capabilities when injected intravenously. The latter property has led to increased research and development activities for intravenous suspensions.