Risk factors for small bowel bleeding in an overt gastrointestinal bleeding presentation after negative upper and lower endoscopy.

Introduction: A small bowel source is suspected when evaluation of overt gastrointestinal (GI) bleeding with upper and lower endoscopy is negative. Video capsule endoscopy (VCE) is the recommended next diagnostic test for small bowel bleeding sources. However, clinical or endoscopic predictive factors for small bowel bleeding in the setting of an overt bleeding presentation are unknown.

Correction to: Risk Factors for Clostridium difficile Isolation in Inflammatory Bowel Disease: A Prospective Study.

The original version of the article unfortunately contained an error in a percentage value in Results section of Abstract.

Risk Factors for Clostridium difficile Isolation in Inflammatory Bowel Disease: A Prospective Study.

Introduction: Clostridium difficile is the most commonly isolated stool pathogen in inflammatory bowel disease (IBD). Traditional risk factors for C. difficile may not exist in patients with IBD, and no prior studies have assessed the risk factors for the isolation of C.

Factors associated with readmission to the hospital within 30 days in patients with inflammatory bowel disease.

Background: Management of inpatients with inflammatory bowel disease (IBD) requires increasing resources. We aimed to identify factors associated with hospital readmissions among individuals with IBD.

Materials & Methods: We collected data from the Healthcare Cost and Utilization Project Nationwide Readmissions Database 2013.

Patients With Ulcerative Colitis and Primary Sclerosing Cholangitis Frequently Have Subclinical Inflammation in the Proximal Colon.

Background & Aims: Patients with primary sclerosing cholangitis (PSC) and ulcerative colitis (UC) have a high risk of colonic neoplasia. Neoplasia frequently develops in the proximal colon in patients with PSC. Histologic inflammation is an independent risk factor for the development of neoplasia; we investigated whether patients with UC and PSC have more subclinical disease activity than patients with UC alone.

Risk Factors for 30-day Hospital Readmission for Diverticular Hemorrhage.

Introduction: The 2010 Affordable Care Act introduced the Hospital Readmissions Reduction Program to reduce health care utilization. Diverticular disease and its complications remain a leading cause of hospitalization among gastrointestinal disease. We sought to determine risk factors for 30-day hospital readmissions after hospitalization for diverticular bleeding.

Northern Latitude but Not Season Is Associated with Increased Rates of Hospitalizations Related to Inflammatory Bowel Disease: Results of a Multi-Year Analysis of a National Cohort.

Background And Aims: There is growing evidence that the incidence and severity of inflammatory bowel disease (IBD) may be geographically and seasonally related. Why these associations are observed remains unclear. We assessed the impact of geographic location, season, and exposure to ultraviolet light on disease severity by measuring national hospital IBD-related discharge rates.

The benefit of paracentesis on hospitalized adults with cirrhosis and ascites.

Background And Aim: The aim of this study is to assess paracentesis utilization and outcomes in hospitalized adults with cirrhosis and ascites.

Methods: The 2011 Nationwide Inpatient Sample was used to identify adults, non-electively admitted with diagnoses of cirrhosis and ascites. The primary endpoint was in-hospital mortality.

Benefit-risk assessment of new and emerging treatments for hepatitis C: focus on simeprevir and sofosbuvir.

Greater understanding of the hepatitis C virus (HCV) genome and life cycle of the HCV virion allows for new targets for therapy that directly act on the viral machinery to inhibit replication. Numerous direct-acting antivirals are in development, and four have been brought to market. Simeprevir, a second-generation protease inhibitor, has been approved for HCV genotype 1 patients in combination with pegylated interferon-α and ribavirin.

Hepatitis C: management of side effects in the era of direct-acting antivirals.

Triple therapy with either boceprevir (BOC) or telaprevir (TVR) in combination with pegylated interferon-alfa (PEG-IFN) and ribavirin (RBV) has given clinicians a more effective armamentarium and has established a new standard of care for the treatment of chronic hepatitis C (CHC). These advances have come with the caveat of continued adverse effects of dual therapy, with a new set of adverse effects related specifically to the protease inhibitors, BOC and TVR. Hematologic, dermatologic, and gastrointestinal adverse effects require careful monitoring and specific interventions, which will assist in completing therapy and achieving SVR.

Does constipation predict the quality of bowel preparation during colonoscopy?

Background: Suboptimal bowel preparation has several consequences, including reduced polyp detection rate and increased cost of colorectal cancer screening. The presence of constipation is thought to be a feature associated with poor bowel preparation.

Objectives: To characterise the relationship between features of constipation and the quality of bowel preparation during colonoscopy.

Laparoscopic donor nephrectomy: intraoperative safety, immediate morbidity, and delayed complications with 500 cases.

Background: Several large series of laparoscopic donor nephrectomy (LDN) have been published, largely focusing on immediate results and short-term complications. The aim of this study was to examine the results of LDN and collect medium-term and long-term donor followup.

Methods: We examined the results of two surgeons who performed 500 consecutive LDNs from 1996 to 2005.

Endoscopic sedation in the United States: results from a nationwide survey.

Objectives: The introduction of new sedative agents as well as a desire for improved patient satisfaction and greater efficiency has changed the practice of endoscopic sedation. This survey was designed to provide national and regional data on endoscopic sedation and monitoring practices within the United States.

Methods: A 22-item survey regarding current practices of endoscopy and sedation was mailed to 5,000 American College of Gastroenterology physician members nationwide.