Publications by authors named "John N DeSimone"
Article Synopsis
- The study focuses on how human skin fibroblasts respond to gamma-irradiation, detailing the processes behind G2 and G1 phase cell cycle arrests.
- Normal fibroblasts and E6-expressing fibroblasts were analyzed to highlight the role of the TP53 protein in these cell cycle changes, revealing that the initiation of G2 arrest is TP53-independent while its maintenance is TP53-dependent.
- The research concludes that after a temporary G2 arrest, normal cells enter a chronic G1 phase arrest, which involves down-regulation of specific proteins, affecting cyclin E/CDK2 activity, while E6-expressing cells continue to cycle through the cell cycle.
