Identification of Psychoactive Degradants of Cannabidiol in Simulated Gastric and Physiological Fluid.

In recent research, orally administered cannabidiol (CBD) showed a relatively high incidence of somnolence in a pediatric population. Previous work has suggested that when CBD is exposed to an acidic environment, it degrades to Δ-tetrahydrocannabinol (THC) and other psychoactive cannabinoids. To gain a better understanding of quantitative exposure, we completed an study by evaluating the formation of psychoactive cannabinoids when CBD is exposed to simulated gastric fluid (SGF).