Publications by authors named "John Marinelli"

Objective: To evaluate cochlear implant speech perception among patients with sporadic inner ear schwannoma who underwent ipsilateral implantation.

Study Design: Retrospective multi-institutional cohort study.

Setting: Eleven tertiary academic medical centers across Germany, Denmark, and the United States.

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Article Synopsis
  • The study aims to evaluate how different cochlear dose parameters affect hearing outcomes in patients with sporadic vestibular schwannoma (VS) who have serviceable hearing after undergoing stereotactic radiosurgery (SRS).
  • A total of 205 patients were analyzed over a period from 2007 to 2022, revealing that 62% of patients maintained serviceable hearing at 2 years, while this dropped to 15% by 10 years post-treatment.
  • Results showed a significant association between increased minimum cochlear dose and faster decline in hearing, indicating that this dose parameter should be a key consideration in planning radiosurgery for VS patients.
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Article Synopsis
  • - This study compares cochlear implant (CI) outcomes for speech perception in patients with sporadic vestibular schwannoma (VS) treated through observation, radiosurgery, or microsurgery.
  • - Of the 100 patients analyzed, those who underwent microsurgery had poorer speech perception scores compared to those who were observed or treated with radiosurgery, with only 61% achieving open-set speech perception after microsurgery.
  • - The findings suggest that cochlear implants can be beneficial for sporadic VS patients, particularly those managed by observation or radiosurgery, as these groups showed significantly better outcomes in achieving open-set speech perception.
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Objective: Stereotactic radiosurgery (SRS) is increasingly used for small-to-medium-sized sporadic vestibular schwannoma (VS) and is associated with good tumor control and low-risk of adverse radiation-associated events. The exact mechanism of VS tumor control is unknown but may relate to microvascular hyalinization and resultant tumoral ischemia. This study examined associations of microvascular risk factors with outcomes following SRS.

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Article Synopsis
  • Over the past two decades, there has been a growing focus on diagnosing and managing inner ear schwannomas, especially regarding hearing rehabilitation through cochlear implants, but the terminology used to classify these tumors has been inconsistent and complex.
  • At the Ninth Quadrennial Conference in May 2023 in Bergen, Norway, experts reached a consensus to standardize terminology, ultimately agreeing on the term "inner ear schwannoma (IES)" to clearly describe tumors affecting the eighth nerve in the cochlea, vestibule, or semicircular canals.
  • The newly established classifications break down these tumors into three complexity levels: low (intravestibular, intracochlear), intermediate (with internal
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Purpose Of Review: Pediatric cochlear implantation has evolved considerably over the past three decades to include more patients at earlier ages with greater degrees of residual hearing. As an extension, a significant focus of research over the past decade has surrounded preservation of existing acoustic hearing.

Recent Findings: Multiple studies published within the last 5 years demonstrate aidable acoustic hearing preservation in 60-90% of pediatric patients, with 40-60% experiencing complete hearing preservation following cochlear implantation.

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Objective: To describe outcomes of patients with sporadic vestibular schwannoma (VS) who underwent repeat stereotactic radiosurgery (SRS) after primary SRS failure.

Study Design: Multi-institutional historical cohort study.

Setting: Five tertiary care referral centers.

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Background: White noise machines are widely used as a sleep aid for young children and may lead to poor hearing, speech, and learning outcomes if used incorrectly.

Objective: Characterize the potential impact of chronic white noise exposure on early childhood development.

Methods: Embase, Ovid MEDLINE, the Cochrane Central Register of Controlled Trials, Scopus, and Web of Science were searched from inception through June 2022 for publications addressing the effects of chronic noise exposure during sleep on early development in animals and children.

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Importance: Management of sporadic vestibular schwannoma with radiosurgery is becoming increasingly common globally; however, limited data currently characterize patient outcomes in the setting of microsurgical salvage for radiosurgical failure.

Objective: To describe the clinical outcomes of salvage microsurgery following failed primary stereotactic radiosurgery (SRS) or fractionated stereotactic radiotherapy (FSRT) among patients with sporadic vestibular schwannoma.

Design, Setting, And Participants: This was a cohort study of adults (≥18 years old) with sporadic vestibular schwannoma who underwent salvage microsurgery following failed primary SRS/FSRT in 7 vestibular schwannoma treatment centers across the US and Norway.

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Article Synopsis
  • The study aims to assess trends in stapedectomy (a type of ear surgery) and ossiculoplasty (repair of ear bones) over a decade before the COVID-19 pandemic to understand the skill retention of these procedures among otolaryngologists.
  • Analysis of over nine million Department of Defense beneficiaries revealed a significant decline in both stapedectomies (down 23%) and ossiculoplasties (down 18%) from 2010 to 2019, indicating a potential shift in surgical focus.
  • The findings suggest that as these surgeries decrease, cochlear implantations may rise, prompting a recommendation to prioritize cochlear implantation training over stapedectomy and ossiculoplasty for medical residents to enhance their future practice.
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Purpose Of Review: The purpose of this review is to outline the temporal bone management of external and middle ear carcinoma. The review will outline the current evidence involved in deciding which surgical approach to take, as well as new advances in auditory rehabilitation and immunotherapy.

Recent Findings: Traditional surgical approaches include lateral temporal bone resection, subtotal temporal bone resection and total temporal bone resection.

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Objective: The treatment paradigm of vestibular schwannoma (VS) focuses on preservation of neurologic function, with small tumors increasingly managed with active surveillance. Often, tumor size and hearing outcomes are poorly correlated. The aim of the current work was to describe the natural history of hearing among patients with nongrowing VS during observational management.

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Objective: To investigate the association between standard pure tone and speech audiometry with neuroimaging characteristics reflective of aging and dementia in older adults.

Study Design: Prospective population-based study.

Setting: Single tertiary care referral center.

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Objective: Limited evidence to date has examined public perceptions of cochlear implants among adult hearing aid users with moderate to profound hearing loss. The current work was conceived with the chief objective of characterizing the perceptions surrounding cochlear implants among the prospective candidate pool.

Study Design: National cross-sectional survey study.

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Objective: The objective of the current study was to present the results of an international working group survey identifying perceived limitations of existing facial nerve grading scales to inform the development of a novel grading scale for assessing early postoperative facial paralysis that incorporates regional scoring and is anchored in recovery prognosis and risk of associated complications.

Study Design: Survey.

Setting: A working group of 48 multidisciplinary clinicians with expertise in skull base, cerebellopontine angle, temporal bone, or parotid gland surgery.

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Introduction: The Department of Defense Medical Examination Review Board (DoDMERB) plays a pivotal role in the assessment of medical fitness for aspiring military officers. A crucial component of this process is the screening audiogram, designed to evaluate hearing capabilities. However, recent observations of high disqualification rates following screening audiograms led to concerns about their accuracy.

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Objective: With ongoing national expansions in cochlear implantation (CI) candidacy criteria, more patients qualify for CI today than ever before. Among US veterans and military service members, the prevalence of qualifying degrees of hearing loss secondary to occupational noise exposure exceeds the general population. The primary aim of the current work was to evaluate CI trends across the military health system.

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Objective: Hearing loss is increasingly recognized as a chronic disease state with important health sequelae. Although considered a central component of routine audiometric testing, the degree to which various patient factors influence speech discrimination is poorly characterized to date. The primary objective of the current work was to describe associations of cognitive performance, sociodemographic factors, and pure-tone audiometry with speech discrimination in older adults.

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Article Synopsis
  • This study analyzes the age and frequency of cochlear implants in young children with severe hearing loss in the U.S., focusing on data from two major implant manufacturers between 2015 and 2019.
  • A total of 4,236 children under 36 months received cochlear implants, with an average age of 16 months at the time of surgery, which remained consistent during the study period.
  • Notably, while more children were receiving implants, and more were getting bilateral implants, the average age of implantation still lagged behind recommended guidelines.
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Objective: In certain cases, clinicians may consider continued observation of a vestibular schwannoma after initial growth is detected. The aim of the current work was to determine if patients with growing sporadic vestibular schwannomas could be stratified by the likelihood of subsequent growth based on initial growth behavior.

Study Design: Slice-by-slice volumetric tumor measurements from 3,505 serial magnetic resonance imaging studies were analyzed from 952 consecutively treated patients.

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Objective: To determine how social media is used in the dissemination of new information within otolaryngology, and to emphasize the importance of standardizing Twitter hashtag use.

Methods: Based on the 2019 SCImago journal rankings, the Twitter posts from the accounts of the top three journals covering each otolaryngology subspecialty were reviewed from August 1, 2020 to May 1, 2021. Twitter posts from the primary otolaryngology-related academic societies were also reviewed during this timeframe.

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Objectives: To investigate the associations of age and year of cochlear implantation (CI) with CI incidence among adults 20 years and older residing in the US.

Study Design: Deidentified cochlear implant data were acquired from prospective patient registries from two cochlear implant manufacturers (Cochlear Americas and Advanced Bionics), which supply an estimated 85% of cochlear implants in the US. Population estimates for severe-to-profound sensorineural hearing loss by age group were extracted from Census and National Health and Nutrition Examination Survey data.

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The focus of management in sporadic vestibular schwannoma has dramatically evolved over the last 100 years. The centrality of quality of life (QoL) is being underscored by an ongoing epidemiologic shift toward an older patient demographic that is being diagnosed with smaller tumors and often with few associated symptoms. Two disease-specific QoL instruments have been developed for sporadic vestibular schwannoma: the Penn Acoustic Neuroma Quality of Life Scale in 2010, and more recently, the Mayo Clinic Vestibular Schwannoma Quality of Life Index in 2022.

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