A two-phase model for smoothly joining disparate growth phases in the macropodid Thylogale billardierii.

Generally, sigmoid curves are used to describe the growth of animals over their lifetime. However, because growth rates often differ over an animal's lifetime a single curve may not accurately capture the growth. Broken-stick models constrained to pass through a common point have been proposed to describe the different growth phases, but these are often unsatisfactory because essentially there are still two functions that describe the lifetime growth.

Microarray analysis identifies candidate genes for key roles in coral development.

Background: Anthozoan cnidarians are amongst the simplest animals at the tissue level of organization, but are surprisingly complex and vertebrate-like in terms of gene repertoire. As major components of tropical reef ecosystems, the stony corals are anthozoans of particular ecological significance. To better understand the molecular bases of both cnidarian development in general and coral-specific processes such as skeletogenesis and symbiont acquisition, microarray analysis was carried out through the period of early development - when skeletogenesis is initiated, and symbionts are first acquired.

Discussion of "A Bayesian approach to DNA sequence segmentation".

This article discusses the results in Boys and Henderson (2004, Biometrics 60, 573-581) in which the authors propose a new approach to the classification of genomic DNA into a number of hidden Markov states with a variable order of dependency, potentially allowing for the high-throughput detection of structure within genomic DNA. This article is likely to be an important point of departure for further modeling of this type. We question whether the genome of the bacteriophage lambda is the most appropriate example with which to demonstrate the method's effectiveness, whether it can be expected that the method will carry over to genomes where there is only one direction of transcription and no operon structure, and suggest a graphical display that seems to offer insight into the results.

An efficient Z-score algorithm for assessing sequence alignments.

We describe an alternative method for scoring of the pairwise alignment of two biological sequences. Designed to overcome the bias due to the composition of the alignment, it measures the distance (in standard deviations) between the given alignment and the mean value of all other alignments that can be obtained by a permutation of either sequence. We demonstrate that the standard deviation can be calculated efficiently.

Applying Lee-Carter under conditions of variable mortality decline.

The Lee-Carter method of mortality forecasting assumes an invariant age component and most applications have adopted a linear time component. The use of the method with Australian data is compromised by significant departures from linearity in the time component and changes over time in the age component. We modify the method to adjust the time component to reproduce the age distribution of deaths, rather than total deaths, and to determine the optimal fitting period in order to address non-linearity in the time component.

Potential effect of population and climate changes on global distribution of dengue fever: an empirical model.

Background: Existing theoretical models of the potential effects of climate change on vector-borne diseases do not account for social factors such as population increase, or interactions between climate variables. Our aim was to investigate the potential effects of global climate change on human health, and in particular, on the transmission of vector-borne diseases.

Methods: We modelled the reported global distribution of dengue fever on the basis of vapour pressure, which is a measure of humidity.