Publications by authors named "John M P Revilla"
Article Synopsis
- Wolfram Syndrome 1 (WFS1) protein is crucial for maintaining healthy β-cell function, and its deficiency leads to diabetes by causing cell dysfunction and death.
- The study shows that WFS1 promotes insulin production and reduces stress in the endoplasmic reticulum (ER), and its loss results in impaired insulin secretion and increased cell death signals.
- Interestingly, reduced levels of WFS1 and insulin are found in the islets of type-2 diabetes patients, suggesting that WFS1 plays a role in the disease's effects on β-cells and highlights its importance in cell survival and function.
