Publications by authors named "John M Mathew"

Objective Carcinoma cervix is one of the major cancers affecting Indian women. Concurrent chemo-radiotherapy is the standard of care in the treatment of carcinoma cervix. We aimed to study the outcomes and toxicity profile of volumetric modulated arc therapy (VMAT), an advanced modality of radiation delivery when used to treat patients with carcinoma cervix.

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Esthesioneuroblastoma (ENB) or olfactory neuroblastoma is a rare malignant neoplasm arising from the neural crest cells of the olfactory epithelium. The optimum treatment for this rare disease is still unclear. Most of the available literature on this rare head and neck tumour is limited to small retrospective series and single institutional reports.

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Article Synopsis
  • The study evaluated the impact of intensity-modulated radiotherapy (IMRT) on dysphagia in patients with laryngo-pharyngeal cancers, finding that the proportion of patients experiencing swallowing difficulties increased significantly from baseline to three and six months post-treatment.
  • Results indicated that 60.6% of patients had dysphagia at six months, with concurrent chemotherapy showing a significant correlation to the severity of these swallowing issues.
  • Additionally, there was a notable worsening of laryngeal edema and voice quality, including decreased vocal frequency and increased roughness, post-treatment.
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Purpose: Hypofractionated post mastectomy radiotherapy (PMRT) is commonly given using conventional radiotherapy technique. Volumetric modulated arc therapy (VMAT) and Intensity modulated radiation therapy (IMRT) are better sparing heart and lungs. This study was conducted to assess the toxicity profile and dosimetry outcomes of patients receiving PMRT using IMRT or VMAT.

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This narrative describes the experience of a radiation oncologist dealing with inequalities among patients and the associated guilt of the treating physician.

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Background: Diffuse leptomeningeal glioneuronal tumor (DLGNT) is a recent addition to the World Health Organization classification schema of brain tumors, under the heading of neuronal and mixed neuronal-glial tumors. DLGNTs have a classic imaging appearance. However, it has often been misdiagnosed owing to its rarity, its resemblance to granulomatous/leptomeningeal etiologies, and the clinical presentation.

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Aim: Patients in the intensive care unit (ICU) have significantly increased mortality rates. Frequently, clinicians are called upon to help families make decisions regarding aggressiveness of care. Having a realistic expectation of outcome is critical for these discussions.

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