Hepatotoxicity associated with CCNU (lomustine) chemotherapy in dogs.

One hundred seventy-nine tumor-bearing dogs were treated with 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) between 1995 and 2001. CCNU was given as a single dose of 50-110 mg/m2 body surface area PO. Treatment interval varied, but the minimal interval between CCNU doses was 3 weeks.

Carcinoma of the apocrine glands of the anal sac in dogs: 113 cases (1985-1995).

Objective: To characterize the signalment, clinical signs, biological behavior, and response to treatment of carcinoma of the apocrine glands of the anal sac in dogs.

Design: Retrospective study.

Animals: 113 dogs with histologically confirmed carcinoma of the apocrine glands of the anal sac.