Publications by authors named "John Liston O'Donnell"
Aims: We describe the varied clinical presentations, barriers in diagnosis and outcomes of anti-HMGCR myopathy in a large national cohort.
Methods: Adults found positive for serum anti-HMGCR autoantibodies via line blot or enzyme-immunoassay followed by immunoprecipitation were included in the study.
Results: Of 75 patients identified, the records of 72 (96 %) described weakness as the presenting symptom.
Background: In 2014 the incidence of anti-HMGCR myopathy in New Zealand was ∼1.7 case/million persons/year.
Objective: Re-estimate the population incidence and assess ethnic variation in those >40-year -olds.
Article Synopsis
- Detecting antidrug antibodies (ADAs) against infliximab or adalimumab is important for monitoring treatment effectiveness, and various methods exist to evaluate ADA levels and their complex sizes.* -
- The study analyzed serum samples from patients using three different ADA detection assays, finding that most samples formed drug-ADA dimer complexes, with multimer presence indicating high potential for neutralizing activity.* -
- Results showed that while multimer presence correlated with ADA concentrations, the relationship varied between treatments; specifically, in infliximab-treated patients, it highlighted a subset with high ADA levels and substantial neutralizing abilities.*
Aims: Cardiac sarcoidosis (CS) is an important cause of mortality in patients with sarcoidosis. The aim of this retrospective cohort study was to characterize the prevalence, incidence, clinical features and outcomes of CS in the southern region of New Zealand.
Methods And Results: 45 patients were identified: 23 fulfilling international classification criteria, 9 fulfilling physician consensus criteria, and 13 classified as possible CS.