Publications by authors named "John Laird"

Background: Cardiovascular diseases (CVD) cause 19 million fatalities each year and cost nations billions of dollars. Surrogate biomarkers are established methods for CVD risk stratification; however, manual inspection is costly, cumbersome, and error-prone. The contemporary artificial intelligence (AI) tools for segmentation and risk prediction, including older deep learning (DL) networks employ simple merge connections which may result in semantic loss of information and hence low in accuracy.

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Background: The risk of cardiovascular disease (CVD) has traditionally been predicted via the assessment of carotid plaques. In the proposed study, AtheroEdge™ 3.0 (AtheroPoint™, Roseville, CA, USA) was designed to demonstrate how well the features obtained from carotid plaques determine the risk of CVD.

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Cardiovascular disease (CVD) diagnosis and treatment are challenging since symptoms appear late in the disease's progression. Despite clinical risk scores, cardiac event prediction is inadequate, and many at-risk patients are not adequately categorised by conventional risk factors alone. Integrating genomic-based biomarkers (GBBM), specifically those found in plasma and/or serum samples, along with novel non-invasive radiomic-based biomarkers (RBBM) such as plaque area and plaque burden can improve the overall specificity of CVD risk.

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Article Synopsis
  • Accurate lung disease diagnosis is essential, and this study explores combining Attention U-Net with Vision Transformers (ViTs) for better segmentation and classification using chest X-rays.
  • The research employs explainability techniques like Grad-CAM++ and Layer-wise Relevance Propagation (LRP) to illuminate model decisions, which is crucial for clinical acceptance.
  • Results show that Attention U-Net achieved high segmentation accuracy, while ViTs significantly outperformed CNNs in classification tasks, ultimately enhancing confidence in AI solutions for healthcare.
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Background And Novelty: When RT-PCR is ineffective in early diagnosis and understanding of COVID-19 severity, Computed Tomography (CT) scans are needed for COVID diagnosis, especially in patients having high ground-glass opacities, consolidations, and crazy paving. Radiologists find the manual method for lesion detection in CT very challenging and tedious. Previously solo deep learning (SDL) was tried but they had low to moderate-level performance.

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Background: The field of precision medicine endeavors to transform the healthcare industry by advancing individualised strategies for diagnosis, treatment modalities, and predictive assessments. This is achieved by utilizing extensive multidimensional biological datasets encompassing diverse components, such as an individual's genetic makeup, functional attributes, and environmental influences. Artificial intelligence (AI) systems, namely machine learning (ML) and deep learning (DL), have exhibited remarkable efficacy in predicting the potential occurrence of specific cancers and cardiovascular diseases (CVD).

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  • The study investigates how well specific features of carotid plaque can predict the risk of coronary artery disease (CAD) and cardiovascular (CV) events using deep learning (DL) compared to traditional machine learning (ML).
  • It involved 459 participants who underwent various imaging techniques, and metrics like maximum plaque height and intraplaque neovascularization were analyzed over a period of 30 days.
  • The results revealed that DL models significantly outperformed ML models in predicting CV events, with intraplaque neovascularization being a key indicator for increased risk.
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  • The classification of miRNA species (Human, Gorilla, Rat, Mouse) is complex due to their intricate relationships and previous methods lack robustness and accuracy.
  • GeneAI 3.0 introduces a novel method that integrates machine learning and deep learning to analyze miRNA sequences by extracting features from their nucleotide patterns using both conventional and contemporary feature sets.
  • The study's findings reveal that deep learning approaches outperform traditional methods, with a demonstrated increase in accuracy and area under the curve (AUC), showcasing the effectiveness of ensemble models with composite features in classifying miRNA sequences.
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Background And Motivation: Coronary artery disease (CAD) has the highest mortality rate; therefore, its diagnosis is vital. Intravascular ultrasound (IVUS) is a high-resolution imaging solution that can image coronary arteries, but the diagnosis software via wall segmentation and quantification has been evolving. In this study, a deep learning (DL) paradigm was explored along with its bias.

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Cardiovascular disease (CVD) related mortality and morbidity heavily strain society. The relationship between external risk factors and our genetics have not been well established. It is widely acknowledged that environmental influence and individual behaviours play a significant role in CVD vulnerability, leading to the development of polygenic risk scores (PRS).

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The proposed memory architecture by Barzykowski and Moulin is compelling, and could be improved by incorporating a rational analysis of the functional roles of involuntary autobiographical memory and déjà vu. Additionally, modeling these phenomena computationally would remove ambiguities from the proposal. We provide examples of past work that illustrate how the phenomena may be described more precisely.

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Background: Cardiovascular disease (CVD) is challenging to diagnose and treat since symptoms appear late during the progression of atherosclerosis. alone are not always sufficient to properly categorize at-risk patients, and are inadequate in predicting cardiac events. Integrating (GBBM) found in plasma/serum samples with novel non-invasive (RBBM) such as plaque area, plaque burden, and maximum plaque height can improve composite CVD risk prediction in the pharmaceutical paradigm.

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  • Skin lesion classification is vital for early detection and management of serious skin conditions, but traditional transfer learning models are not performing optimally.
  • A novel method combining attention mechanisms with ensemble-based deep learning techniques has been developed, using seven pre-trained models to improve classification accuracy significantly.
  • The study reports a mean accuracy increase from 95.30% to 99.52% with ensemble approaches, demonstrating high reliability and effectiveness for classifying skin lesions.
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The challenges associated with diagnosing and treating cardiovascular disease (CVD)/Stroke in Rheumatoid arthritis (RA) arise from the delayed onset of symptoms. Existing clinical risk scores are inadequate in predicting cardiac events, and conventional risk factors alone do not accurately classify many individuals at risk. Several CVD biomarkers consider the multiple pathways involved in the development of atherosclerosis, which is the primary cause of CVD/Stroke in RA.

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The global mortality rate is known to be the highest due to cardiovascular disease (CVD). Thus, preventive, and early CVD risk identification in a non-invasive manner is vital as healthcare cost is increasing day by day. Conventional methods for risk prediction of CVD lack robustness due to the non-linear relationship between risk factors and cardiovascular events in multi-ethnic cohorts.

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Background And Motivation: Lung computed tomography (CT) techniques are high-resolution and are well adopted in the intensive care unit (ICU) for COVID-19 disease control classification. Most artificial intelligence (AI) systems do not undergo generalization and are typically overfitted. Such trained AI systems are not practical for clinical settings and therefore do not give accurate results when executed on unseen data sets.

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: The price of medical treatment continues to rise due to (i) an increasing population; (ii) an aging human growth; (iii) disease prevalence; (iv) a rise in the frequency of patients that utilize health care services; and (v) increase in the price. Artificial Intelligence (AI) is already well-known for its superiority in various healthcare applications, including the segmentation of lesions in images, speech recognition, smartphone personal assistants, navigation, ride-sharing apps, and many more. Our study is based on two hypotheses: (i) AI offers more economic solutions compared to conventional methods; (ii) AI treatment offers stronger economics compared to AI diagnosis.

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A diabetic foot infection (DFI) is among the most serious, incurable, and costly to treat conditions. The presence of a DFI renders machine learning (ML) systems extremely nonlinear, posing difficulties in CVD/stroke risk stratification. In addition, there is a limited number of well-explained ML paradigms due to comorbidity, sample size limits, and weak scientific and clinical validation methodologies.

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Background: Endovascular treatment of femoropopliteal artery disease has shifted toward drug-coated balloons (DCB). However, limited data are available regarding the safety and efficacy of DCB vs bare-metal stents (BMS).

Objectives: The purpose of this study was to compare DCB vs BMS outcomes in a propensity-adjusted, pooled analysis of 4 prospective, multicenter trials.

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Stroke and cardiovascular diseases (CVD) significantly affect the world population. The early detection of such events may prevent the burden of death and costly surgery. Conventional methods are neither automated nor clinically accurate.

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Objective: Cardiovascular disease (CVD) is a major healthcare challenge and therefore early risk assessment is vital. Previous assessment techniques use either "conventional CVD risk calculators (CCVRC)" or machine learning (ML) paradigms. These techniques are ad-hoc, unreliable, not fully automated, and have variabilities.

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Background: Drug-coated balloons (DCB) are frequently used to treat femoropopliteal artery disease. However, patency loss occurs in ≥10% of patients within 12 months posttreatment with poor understanding of the underlying mechanisms.

Objectives: The authors sought to investigate the determinants of DCB failure in femoropopliteal disease.

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Article Synopsis
  • Brain tumor characterization (BTC) involves understanding the causes and characteristics of brain tumors through methods like tumor segmentation, detection, and risk analysis, emphasizing the identification of molecular signatures linked to tumor formation.
  • The integration of radiomics and genomics, termed "radiogenomics," leverages AI to enhance disease characterization and enable personalized treatment strategies.
  • A study using the PRISMA search approach identified 121 relevant studies, demonstrating that both radiomics and radiogenomics significantly benefit oncology applications, ultimately improving outcomes through advanced AI techniques while addressing potential biases in research.
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The SARS-CoV-2 virus has caused a pandemic, infecting nearly 80 million people worldwide, with mortality exceeding six million. The average survival span is just 14 days from the time the symptoms become aggressive. The present study delineates the deep-driven vascular damage in the pulmonary, renal, coronary, and carotid vessels due to SARS-CoV-2.

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