Publications by authors named "John L Sensintaffar"
Page 1 of 1
Synopsis of recent research by authors named "John L Sensintaffar"
- John L. Sensintaffar's recent research primarily focuses on discovering and optimizing small molecule inhibitors targeting key proteins involved in cancer, particularly myeloid cell leukemia 1 (Mcl-1) and WD repeat domain 5 (WDR5), which are associated with various cancer types and resistance to therapies.
- His studies highlight the role of Mcl-1 in apoptosis regulation and its correlation with high tumor grade and poor survival, leading to the development of robust inhibitors that show promise in preclinical models for hematological and solid tumors.
- Additionally, his work on WDR5 explores its essential function in oncogenesis and chromatin processes, resulting in innovative inhibitors that demonstrate both efficacy and safety in animal studies, marking significant strides in anti-cancer drug discovery.
