Publications by authors named "John L Kiappes"
Adv Exp Med Biol
November 2018
Article Synopsis
- Targeting the endoplasmic reticulum quality control (ERQC) pathway is proposed as a promising antiviral strategy by focusing on two essential ER resident α-glucosidases.
- Researchers have determined the crystal structures of murine α-glucosidase II, revealing important details about its structure and the effects of specific antiviral iminosugar inhibitors, some of which are in clinical trials for dengue fever.
- The study uncovers new regions of the enzyme that affect its function and shows how the enzyme's structure changes when it interacts with glycoproteins, providing insights into its substrate specificity and activity.
