Publications by authors named "John K Tung"
Recent studies support the development of cancer therapeutics to target Globo H-ceramide, the most prevalent tumor-associated carbohydrate antigen in epithelial cancers. Herein, we evaluated the expression of Globo H and its prognostic significance in intrahepatic cholangiocarcinoma (ICC) and conducted preclinical studies to assess the antitumor activity of Globo H-specific antibody in thioacetamide (TAA)-induced ICC in rats. Globo H-ceramide in tumor specimens was detected by immunohistochemistry (IHC) and mass spectrometry.
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- The immune tumor microenvironment (TME) in neuroblastoma affects tumor behavior and treatment outcomes, with T cells and NK cells being significant players.
- This study focuses on the clinical importance of natural killer T cells (NKTs) and interleukin-15 (IL-15) in neuroblastoma, revealing that both are lower in MYCN-amplified cases compared to MYCN-non-amplified ones.
- Patients with low NKT immunoscore and IL-15 expression showed worse event-free survival (EFS) and overall survival (OS), suggesting a potential benefit in incorporating IL-15 and NKT cell therapy into neuroblastoma treatments.