Publications by authors named "John K Khoo"
Article Synopsis
- - The FUTURE-AS Registry is a study designed to evaluate the effectiveness and safety of using computed tomography coronary angiography (CTCA) and fractional flow reserve (FFR) for assessing coronary artery disease (CAD) in patients with severe aortic stenosis (AS) who are candidates for transcatheter aortic valve replacement (TAVR).
- - The study will measure key outcomes such as the accuracy of CTCA and FFR in detecting significant CAD compared to traditional methods, as well as the safety of the procedures with respect to potential complications.
- - By exploring the feasibility of these imaging techniques, the registry aims to determine if they can help reduce unnecessary invasive procedures before TAVR, ultimately improving patient care.
Background: Cardiogenic shock complicating acute myocardial infarction is associated with reduced survival despite advancements in the treatment of acute coronary syndromes. Characterizing predictors of morbidity and mortality in this setting is crucial to improving risk stratification and management. Notwithstanding, the interplay of factors determining survival in this condition remains poorly studied.
View Article and Find Full Text PDFHypertrophic cardiomyopathy (HCM) is a common genetic disorder with a well described risk of sudden cardiac death; however, risk stratification has remained a challenge. Recently, novel parameters in cardiac magnetic resonance imaging (CMR) have shown promise in helping to improve upon current risk stratification paradigms. In this manuscript, we have reviewed novel CMR risk markers and their utility in HCM.
View Article and Find Full Text PDFBackground: Biodegradable suture anchors are associated with higher redislocation rates. This study examined whether the biocompatibility and/or biomechanical properties of suture anchors contribute to the increase in complications.
Methods: Human glenohumeral capsule cells were cultured with 4 types of suture anchors, Opus LabraFix (titanium alloy; ArthroCare, Austin, TX, USA), PushLock (poly-ether-ether-ketone; Arthrex, Naples, FL, USA), BioKnotless (poly-l-lactic acid; DePuy Mitek, Warsaw, IN, USA), and Suretac II (polyglycolic acid; Smith & Nephew, London, UK), to measure cell viability and pH.
Recent studies of genetic dysfunction in pelvic organ prolapse: the role of collagen defects.
Aust N Z J Obstet Gynaecol
June 2014
Gynaecologists are becoming increasingly aware that women with a family history of prolapse are at an increased risk of prolapse refractory to treatment. In the past five years, several genetic mutations have been shown to correlate with increased prolapse susceptibility. These mutations can result in disordered collagen metabolism, which weaken the fascial support of the pelvic organs.
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