Molecular characterization of a novel p.R118C mutation in the insulin receptor gene from patients with severe insulin resistance.

Context: Mutations of the insulin receptor gene (INSR) can cause genetic syndromes associated with severe insulin resistance.

Objectives: We aimed to analyse INSR mutations in Saudi patients with severe insulin resistance.

Design: Ten patients with Type A insulin resistance syndrome from five unrelated Saudi families were investigated.

Preliminary evaluation of two radioiodinated maleimide derivatives targeting peripheral and membrane sulfhydryl groups for in vitro cell labeling.

A factor impeding the advancement of cell mediated therapy is the inability to track these cells in vivo by noninvasive techniques. It has been shown that cells express high levels of sulfhydryl groups. We sought to explore these groups to covalently label cells with radiolabeled maleimide derivatives.

Radioiodinated naphthylalanine derivatives targeting pancreatic beta cells in normal and nonobese diabetic mice.

An imaging method capable of using a signal from pancreatic beta cells to determine their mass would be of immense value in monitoring the progression of diabetes as well as response to treatment. Somatostatin receptors (SSTRs) are expressed on beta cells and are a potential target for imaging. The main objective of this study was to investigate whether pancreatic beta cells are a target for radiolabeled naphthylalanine derivatives.