Traditional and non-traditional cardiovascular risk factor profiles in young patients with coronary artery disease.

Study Objective: There is an increasing trend in myocardial infarction (MI) hospitalizations in young individuals. The prevalence of modifiable cardiovascular risk factors is high in this population. This study aims to assess the prevalence of traditional and non-traditional cardiovascular risk factors among young patients with coronary artery disease (CAD) including novel lipid and dietary biomarkers with a focus on potential gender differences.

A system approach to improving guideline-directed therapy for cardio-renal-metabolic conditions: The "beyond diabetes" initiative.

Objective: Despite demonstrating improvements in cardiovascular disease, kidney disease, and survival outcomes, guideline-directed antihyperglycemic medications such as sodium-glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like-peptide-1 receptor agonists (GLP1-RA), are underutilized. Many obstacles constrain their use including lack of systematic provider and patient education, concern for medication side effects, and patient affordability.

Methods: We designed a multimodality, systems-based approach to address these challenges with the goal of increasing medication utilization across the largest healthcare system in New York State.

Promoting solution-phase superlattices of CsPbBr nanocrystals.

We present a size-selective method for purifying and isolating perovskite CsPbBr nanocrystals (NCs) that preserves their as-synthesized surface chemistry and extremely high photoluminescence quantum yields (PLQYs). The isolation procedure is based on the stepwise evaporation of nonpolar co-solvents with high vapor pressure to promote precipitation of a size-selected product. As the sample fractions become more uniform in size, we observe that the NCs self-assemble into colloidally stable, solution-phase superlattices (SLs).

Antagonism of nonaflatoxigenic isolated from peanuts against aflatoxigenic growth and aflatoxin B production .

section constitutes several species of opportunistic fungi, notable among them are and , capable of surviving harsh conditions and colonizing a wide range of agricultural products pre- and postharvest. Physical and chemical control methods are widely applied in order to mitigate the invasion of in crops. However, physical control is not suitable for large scale and chemical control often leads to environmental pollution, whereas biological control offers a safer, environmentally friendly, and economical alternative.

Bacillus Calmette-Guerin (BCG): the adroit vaccine.

Background: The Bacillus Calmette-Guerin (BCG) vaccine has been in use for 99 years, and is regarded as one of the oldest human vaccines known today. It is recommended primarily due to its effect in preventing the most severe forms of tuberculosis, including disseminated tuberculosis and meningeal tuberculosis in children; however, its efficacy in preventing pulmonary tuberculosis and TB reactivation in adults has been questioned. Several studies however have found that asides from its role in tuberculosis prevention, the BCG vaccine also has protective effects against a host of other viral infections in humans, an effect which has been termed: heterologous, non-specific or off-target.

COVID-19 outcomes in UK centre within highest health and wealth band: a prospective cohort study.

Objectives: To describe the characteristics and outcomes of hospitalised patients with COVID-19 from UK in the highest decile of health and gross regional products per capita.

Design: Prospective cohort study.

Setting: Recruited all adult inpatients with laboratory-confirmed COVID-19 symptoms admitted to a single Surrey centre between March and April 2020.

Expanded Scope of Bacillus Calmette-Guerin (BCG) Vaccine Applicability in Disease Prophylaxis, Diagnostics, and Immunotherapeutics.

Following the discovery of the Bacillus Calmette-Guerin (BCG) vaccine, its efficacy against was soon established, with several countries adopting universal BCG vaccination schemes for their populations. Soon, however, studies aimed to further establish the efficacy of the vaccine in different populations discovered that the vaccine has a larger effect in reducing mortality rate than could be explained by its effect on tuberculosis alone, which sparked suggestions that the BCG vaccine could have effects on other unrelated or non-mycobacterial pathogens causing diseases in humans. These effects were termed heterologous, non-specific or off-target effects and have been shown to be due to both innate and adaptive immune system responses.

Modelling the effect of temperature and water activity on the growth rate of Aspergillus flavus and aflatoxin production in peanut meal extract agar.

Aspergillus flavus is the predominant species that produce aflatoxins in stored peanuts under favourable conditions. This study aimed to describe the growth and aflatoxin production by two A. flavus strains isolated from imported raw peanuts and to model the effects of temperature and a on their colony growth rate as a function of temperature and a in Peanut Meal Extract Agar (PMEA).

AUTOMATIC BRAIN ORGAN SEGMENTATION WITH 3D FULLY CONVOLUTIONAL NEURAL NETWORK FOR RADIATION THERAPY TREATMENT PLANNING.

3D organ contouring is an essential step in radiation therapy treatment planning for organ dose estimation as well as for optimizing plans to reduce organs-at-risk doses. Manual contouring is time-consuming and its inter-clinician variability adversely affects the outcomes study. Such organs also vary dramatically on sizes - up to two orders of magnitude difference in volumes.

The effects of different packaging materials, temperatures and water activities to control aflatoxin B production by and in stored peanuts.

Aflatoxins (AFs) are secondary metabolites produced by aflatoxigenic strains of and , the most toxic being aflatoxin B (AFB). The purpose of the present work was to investigate the effects of industrial-grade packaging materials (low-density polyethylene, polypropylene, polyethylene-laminated aluminium); temperatures (25 °C, 30 °C); and water activities (0.74 , 0.

The effect of γ-tACS on working memory performance in healthy controls.

Transcranial Direct Current Stimulation (tDCS) has been widely investigated for its potential to enhance cognition, and in particular working memory, however to date standard approaches to stimulation have shown only modest effects. Alternative, more specialised, forms of current delivery may be better suited to cognitive enhancement. One such method is transcranial Alternating Current Stimulation (tACS) which delivers stimulation at a specific frequency and has been shown to entrain endogenous cortical oscillations which underlie cognitive functioning.

Proton affinities of deoxyribonucleosides via the ONIOM-ccCA methodology.

Utilizing the recently developed ONIOM-ccCA methodology, the proton affinities (PAs) of small biomolecules (∼15 nonhydrogen atoms) were determined. The ONIOM-ccCA method was used to predict the PAs of eight amine-containing molecules and these predictions were then compared with experiment. In these comparisons, a protocol for the determination of the model system size was established, and the low level method and basis set for the real system component of ONIOM-ccCA were considered.

Clinical and microbiologic characteristics of invasive Streptococcus pyogenes infections in north and south India.

The lack of epidemiologic data on invasive Streptococcus pyogenes infections in many developing countries is concerning, as S. pyogenes infections are commonly endemic in these areas. Here we present the results of the first prospective surveillance study of invasive Streptococcus pyogenes infections in India.