Publications by authors named "John Jongerius"
Each year, blood transfusions save millions of lives. However, under current blood-matching practices, sensitization to non-self-antigens is an unavoidable adverse side effect of transfusion. We describe a universal donor typing platform that could be adopted by blood services worldwide to facilitate a universal extended blood-matching policy and reduce sensitization rates.
View Article and Find Full Text PDFArticle Synopsis
- The study addresses the challenge of finding Vel-negative blood donors for patients with anti-Vel alloantibodies, as these donors are rare (1 in 4000).
- Researchers developed a recombinant anti-Vel monoclonal antibody that effectively identifies both Vel-negative and weak Vel-expressing red blood cells, surpassing existing human anti-Vel sera in accuracy.
- The new antibody (M3F5S-IgM) can be used in various testing methods, increasing the availability of Vel-negative blood donations by discovering new potential donors through high-throughput screening.
Background: Alloantibodies directed against antigens of the Kell blood group system are clinically significant. In the Netherlands, the KEL1 antigen is determined in all blood donors. In this study, after phenotyping of KEL:1-positive donors, genotyping analysis was conducted in KEL:1,-2 donors to identify possible KEL*02 variant alleles.
View Article and Find Full Text PDFBackground: Routine HCV NAT minipool screening (48 donations) of all blood donations was implemented in July 1999 and was combined with HIV NAT in November 2000. This report describes the validation of the NAT methods and the results of quality control testing.
Study Design And Methods: Nucleic acid was extracted from 2-mL plasma samples by using an automated silica-based extraction method (NucliSens Extractor, Organon Teknika).