Frequent low-impact exposure to THC during adolescence causes persistent sexually dimorphic alterations in the response to viral infection in mice.

Adolescent exposure to Δ-tetrahydrocannabinol (THC) has enduring effects on energy metabolism and immune function. Prior work showed that daily administration of a low-impact dose of THC (5 mg/kg, intraperitoneal) during adolescence alters transcription in adult microglia and disrupts their response to bacterial endotoxin or social stress. To explore the lasting impact of adolescent THC exposure on the brain's reaction to viral infection, we administered THC (5 mg/kg, intraperitoneal) in male and female mice once daily on postnatal day (PND) 30-43.

Do clinicians use the American College of Radiology Appropriateness criteria in the management of their patients?

Objective: The purpose of this study was to investigate the use of the American College of Radiology (ACR) appropriateness criteria by referring physicians during decision making about imaging in the management of their patients.

Conclusion: There is a low utilization of the ACR appropriateness criteria by clinicians when ordering imaging studies for their patients. The ACR has invested a great deal of resources in these criteria and should therefore be aware of information regarding utilization.