Publications by authors named "John J Vennemeyer"
Short and long gap peripheral nerve repair with magnesium metal filaments.
J Biomed Mater Res A
November 2017
Article Synopsis
- A study explored the use of biodegradable magnesium filaments within nerve conduits to replace autografts for repairing peripheral nerve injuries in adult rats.
- Results showed that magnesium filaments supported nerve repair, with better axon growth compared to empty conduits or those with titanium filaments, especially after a 6 mm gap and 6 weeks post-repair.
- Despite less improvement in nerve regeneration with longer gaps (15 mm) and more time (16 weeks), magnesium filaments demonstrated biocompatibility and enhanced tissue conditions compared to empty conduits, making them a promising option for future nerve repair strategies.
Because a potential treatment for brain injuries could be elevating magnesium ions (Mg(2+)) intracerebrally, we characterized the effects of elevating external Mg(2+) in cultures of neonatal murine brain-derived neural stem/progenitor cells (NSCs). Using a crystal violet assay, which avoids interference of Mg(2+) in the assay, it was determined that substrate influenced Mg(2+) effects on cell numbers. On uncoated plastic, elevating Mg(2+) levels to between 2.
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