Publications by authors named "John J Thompson"
Approximately 60-70 million people suffer from traumatic brain injury (TBI) each year. Animal models continue to be paramount in understanding mechanisms of cellular dysfunction and testing new treatments for TBI. Enhancing the translational potential of novel interventions therefore necessitates testing pre-clinical intervention strategies with clinically relevant cognitive assays.
View Article and Find Full Text PDFIt is well established that degradation of perforant path fibers is associated with age-related cognitive dysfunction and CA3 hyperactivity. Whether this fiber loss triggers a cascade of other functional changes within the hippocampus circuit has not been causatively established, however. Thus, the current study evaluated the effect of perforant path fiber loss on neuronal activity in CA3 and layer II of the lateral entorhinal cortex (LEC) in relation to mnemonic similarity task performance.
View Article and Find Full Text PDFArticle Synopsis
- - The study focused on how colorectal cancer is diagnosed in a military health care setting, comparing detection through screening methods versus symptomatic evaluation.
- - Out of 197 diagnosed cases, 25% were found through screening tests, while 75% were identified after symptoms appeared, often indicating more advanced stages of cancer.
- - Screening methods like fecal occult blood tests were linked to early-stage diagnoses, while common symptoms included rectal bleeding and abdominal pain, showing that timely screening is crucial despite equal access to medical services.