psHarmonize: Facilitating reproducible large-scale pre-statistical data harmonization and documentation in R.

Combining pertinent data from multiple studies can increase the robustness of epidemiological investigations. Effective "pre-statistical" data harmonization is paramount to the streamlined conduct of collective, multi-study analysis. Harmonizing data and documenting decisions about the transformations of variables to a common set of categorical values and measurement scales are time consuming and can be error prone, particularly for numerous studies with large quantities of variables.

Comparative cardiovascular effects of GLP-1 agonists using real-world data.

Aims: There is limited research using real-world data to evaluate protective cardiovascular effects of glucagon-like peptide-1 (GLP-1) agonists among adults with type 2 diabetes (T2D) early in treatment.

Materials And Methods: We conducted a retrospective, active comparator cohort study using 2011-2015 administrative claims data to compare cardiovascular disease (CVD) event rates following initiation of exenatide extended-release (E-ER), exenatide immediate-release (E-IR) or liraglutide in T2D adults who previously received no other antidiabetic medication (ADM) except metformin. The primary outcome was time to first major adverse CVD event (ischaemic heart disease, stroke, congestive heart failure or peripheral arterial disease) after starting GLP-1.

Integrating diabetes technologies with team-based primary care for type 2 diabetes: A pilot trial.

This pilot trial studied a novel intervention that integrated diabetes technologies into team-based primary care for type 2 diabetes. We found clinically significant reductions in blood pressure, weight, and glucose. The latter two were statistically significant.