Publications by authors named "John Hortareas"
ACS Pharmacol Transl Sci
October 2024
Article Synopsis
- Mitochondrial dysfunction, inflammation, fibrosis, and cell aging play significant roles in the transition from acute kidney injury (AKI) to chronic kidney disease, although the specific cellular processes involved are still being studied.
- Recent research has identified key factors at the single-cell level that affect the repair processes in the kidneys after ischemia-reperfusion injury, with a focus on the role of the drug lasmiditan.
- The study found that lasmiditan treatment enhances the expression of genes associated with successful kidney repair and reduces the expression of maladaptive repair genes, suggesting it could be a promising therapeutic option for improving kidney recovery after AKI.
