Publications by authors named "John Hinton"
Article Synopsis
- Generalized myasthenia gravis (gMG) is a chronic disease that significantly affects patients' quality of life and highlights the need for better treatments.
- The ongoing phase III study evaluates the long-term safety and effectiveness of the drug zilucoplan in patients with acetylcholine receptor autoantibody-positive gMG.
- Results from 200 patients showed that a significant majority experienced treatment-emergent adverse events, but those receiving zilucoplan showed continued improvements in daily living activities over 60 weeks, especially after switching from a placebo.
Article Synopsis
- Generalised myasthenia gravis is a rare and difficult-to-manage disease that has a high treatment burden, highlighting the need for better therapies; zilucoplan, a self-administered treatment, was tested in this context.
- The RAISE trial was a phase 3 study conducted across 75 sites in multiple countries, comparing zilucoplan with a placebo in patients diagnosed with AChR-positive myasthenia gravis over a 12-week period.
- Results indicated that patients receiving zilucoplan experienced a significant reduction in their MG-ADL scores compared to those on placebo, suggesting it may be an effective treatment option.
Article Synopsis
- Many patients with generalized myasthenia gravis (gMG) experience significant disability and need better therapies that are well-tolerated to improve their quality of life.
- A phase 2 clinical trial was conducted to assess the effects of zilucoplan, a self-administered injectable treatment, on patients with moderate to severe gMG.
- The study included 44 participants and compared the effectiveness of zilucoplan against a placebo over 12 weeks, focusing on changes in their disease symptoms and daily functioning.
Introduction: To describe treatment patterns in newly diagnosed rheumatoid arthritis (RA) patients in a large, nationally representative managed-care database.
Methods: Newly diagnosed RA patients were identified from 07/01/2006-08/31/2014. Patients had ≥ 1 RA diagnosis by a rheumatologist, or ≥ 2 non-rheumatologist RA diagnoses ≥ 30 days apart, or RA diagnosis followed by a disease-modifying antirheumatic drug (DMARD) prescription fill within 1 year.
Efficient noninvasive techniques are desired for monitoring the remediation process of contaminated soils. We applied the direct current resistivity technique to image conductivity changes in sandbox experiments where two sandy and clayey soils were initially contaminated with diesel hydrocarbon. The experiments were conducted over a 230 day period.
View Article and Find Full Text PDFNoise mapping is a method of presenting complex noise information in a clear and simple way either on a physical map or in a database. This mapping information can be either calculated or measured using a variety of techniques and methods. Furthermore, the results of such exercises can be presented in many different ways and used for a number of different purposes.
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